Genomic Tools

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since most mRNA and microRNA (miRNA) are known, and can be assessed using arrays or RNAseq, they offer unique insight into the molecular biology of ischemic stroke and hemorrhage. Although no one blood mRNA or miRNA can diagnose stroke or hemorrhage, panels or profiles of mRNAs/miRNA can distinguish ischemic stroke from intracerebral hemorrhage and control patients. There are also specific profiles of mRNA and miRNA in blood for large-vessel, cardioembolic, and lacunar causes of stroke that can be used to predict the causes of cryptogenic stroke. There are also specific profiles for patients with ischemic compared with nonischemic transient neurological events, and profiles within 3. h of a stroke that predict which patients will develop hemorrhagic transformation following tissue plasminogen activator.

Original languageEnglish (US)
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages343-345
Number of pages3
ISBN (Print)9780128030585
DOIs
StatePublished - Mar 7 2017

Keywords

  • Alternative splicing
  • Arrays
  • Blood
  • Genomics
  • Intracerebral hemorrhage
  • MiRNA
  • MRNA
  • RNAseq
  • Stroke
  • Stroke causes
  • TIAs

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Sharp, F. R., Jickling, G. C., & Stamova, B. (2017). Genomic Tools. In Primer on Cerebrovascular Diseases: Second Edition (pp. 343-345). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803058-5.00072-2