Genomic sequencing and precision medicine in head and neck cancers

R. C. Hoesli, M. L. Ludwig, N. L. Michmerhuizen, A. J. Rosko, M. E. Spector, J. C. Brenner, A. C. Birkeland

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Head and neck squamous cell carcinoma (HNSCC) remains a common and deadly disease. Historically, surgical and chemoradiation treatments have been met with modest success, and understanding of genetic drivers of HNSCC has been limited. With recent next generation sequencing studies focused on HNSCC, we are beginning to understand the genetic landscape of HNSCCs and are starting to identify and advance targeted options for patients. In this review, we describe current knowledge and recent advances in sequencing studies of HNSCC, discuss current limitations and future directions for further genomic analysis, and highlight the translational advances being undertaken to treat this important disease.

Original languageEnglish (US)
Pages (from-to)884-892
Number of pages9
JournalEuropean Journal of Surgical Oncology
Volume43
Issue number5
DOIs
StatePublished - May 2017
Externally publishedYes

Keywords

  • Genomics
  • Head and neck cancer
  • HNSCC
  • Personalized medicine
  • Precision medicine

ASJC Scopus subject areas

  • Surgery
  • Oncology

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  • Cite this

    Hoesli, R. C., Ludwig, M. L., Michmerhuizen, N. L., Rosko, A. J., Spector, M. E., Brenner, J. C., & Birkeland, A. C. (2017). Genomic sequencing and precision medicine in head and neck cancers. European Journal of Surgical Oncology, 43(5), 884-892. https://doi.org/10.1016/j.ejso.2016.12.002