Genomic Perspectives of Transcriptional Regulation in Forebrain Development

Alexander Nord, Kartik Pattabiraman, Axel Visel, John L.R. Rubenstein

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

The forebrain is the seat of higher-order brain functions, and many human neuropsychiatric disorders are due to genetic defects affecting forebrain development, making it imperative to understand the underlying genetic circuitry. Recent progress now makes it possible to begin fully elucidating the genomic regulatory mechanisms that control forebrain gene expression. Herein, we discuss the current knowledge of how transcription factors drive gene expression programs through their interactions with cis-acting genomic elements, such as enhancers; how analyses of chromatin and DNA modifications provide insights into gene expression states; and how these approaches yield insights into the evolution of the human brain.

Original languageEnglish (US)
Pages (from-to)27-47
Number of pages21
JournalNeuron
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2015

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Prosencephalon
Gene Expression
Brain
Chromatin
Transcription Factors
DNA

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Genomic Perspectives of Transcriptional Regulation in Forebrain Development. / Nord, Alexander; Pattabiraman, Kartik; Visel, Axel; Rubenstein, John L.R.

In: Neuron, Vol. 85, No. 1, 01.01.2015, p. 27-47.

Research output: Contribution to journalReview article

Nord, Alexander ; Pattabiraman, Kartik ; Visel, Axel ; Rubenstein, John L.R. / Genomic Perspectives of Transcriptional Regulation in Forebrain Development. In: Neuron. 2015 ; Vol. 85, No. 1. pp. 27-47.
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