Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon

Shiladitya DasSarma, Sean P. Kennedy, Brian Berquist, Wailap Victor Ng, Nitin S. Baliga, John L. Spudich, Mark P. Krebs, Jonathan A Eisen, Carl H. Johnson, Leroy Hood

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Halobacterium species display a variety of responses to light, including phototrophic growth, phototactic behavior, and photoprotective mechanisms. The complete genome sequence of Halobacterium species NRC-1 (Proc Natl Acad Sci USA 97: 12176-12181, 2000), coupled with the availability of a battery of methods for its analysis makes this an ideal model system for studying photobiology among the archaea. Here, we review: (1) the structure of the 2.57 Mbp Halobacterium NRC-1 genome, including a large chromosome, two minichromosomes, and 91 transposable IS elements; (2) the purple membrane regulon, which programs the accumulation of large quantities of the light-driven proton pump, bacteriorhodopsin, and allows for a period of phototrophic growth; (3) components of the sophisticated pathways for color-sensitive phototaxis; (4) the gas vesicle gene cluster, which codes for cell buoyancy organelles; (5) pathways for the production of carotenoid pigments and retinal, (6) processes for the repair of DNA damage; and (7) putative homologs of circadian rhythm regulators. We conclude with a discussion of the power of systems biology for comprehensive understanding of Halobacterium NRC-1 photobiology.

Original languageEnglish (US)
Pages (from-to)3-17
Number of pages15
JournalPhotosynthesis Research
Volume70
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Photobiology
Halobacterium
Phototrophic Processes
Genes
genomics
DNA Transposable Elements
Bacteriorhodopsins
Proton Pumps
Retinal Pigments
Purple Membrane
Genome
Carotenoids
Chromosomes
Buoyancy
Light
Regulon
regulon
phototaxis
proton pump
Systems Biology

Keywords

  • Archaea
  • Bacteriorhodopsin
  • Carotenoids
  • Circadian rhythm
  • DNA repair
  • Gas vesicles
  • Halobacteria
  • Retinal
  • Sensory rhodopsin
  • Systems biology

ASJC Scopus subject areas

  • Plant Science

Cite this

Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon. / DasSarma, Shiladitya; Kennedy, Sean P.; Berquist, Brian; Ng, Wailap Victor; Baliga, Nitin S.; Spudich, John L.; Krebs, Mark P.; Eisen, Jonathan A; Johnson, Carl H.; Hood, Leroy.

In: Photosynthesis Research, Vol. 70, No. 1, 2001, p. 3-17.

Research output: Contribution to journalArticle

DasSarma, S, Kennedy, SP, Berquist, B, Ng, WV, Baliga, NS, Spudich, JL, Krebs, MP, Eisen, JA, Johnson, CH & Hood, L 2001, 'Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon', Photosynthesis Research, vol. 70, no. 1, pp. 3-17. https://doi.org/10.1023/A:1013879706863
DasSarma, Shiladitya ; Kennedy, Sean P. ; Berquist, Brian ; Ng, Wailap Victor ; Baliga, Nitin S. ; Spudich, John L. ; Krebs, Mark P. ; Eisen, Jonathan A ; Johnson, Carl H. ; Hood, Leroy. / Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon. In: Photosynthesis Research. 2001 ; Vol. 70, No. 1. pp. 3-17.
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