Genomic abnormalities in patients with migraine and chronic migraine: Preliminary blood gene expression suggests platelet abnormalities

Andrew D. Hershey, Yang Tang, Scott W. Powers, Marielle A. Kabbouche, Donald L. Gilbert, Tracy A. Glauser, Frank R Sharp

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background. - Migraine has strong genetic and environmental components and may also be a significant contributor to chronic migraine (CM). It is hypothesized that gene expression changes in peripheral blood cells can be used to detect the interaction of these influences. Objective. - Distinct genomic expression patterns for migraine and CM will be present. These genomic profiles will help clarify the interactions of inheritance and environment. This initial study begins to examine the feasibility of peripheral blood cell genomic analysis to assist in the understanding of the pathophysiology of migraine and CM. Methods. - Blood samples from patients were obtained either during an acute migraine or CM. Genomic expression patterns were analyzed using Affymetrix U95A microarrays. Results. - Expression patterns of 7 migraine and 15 CM patients were compared to four distinct control groups (total patients, n = 56) including healthy subjects. A group of platelet genes were upregulated in both migraine and CM samples. Different gene expression patterns were also seen between migraine and CM. A group of immediate early genes including c-fos and cox-2 were expressed at higher levels in migraine, whereas specific mitochondrial genes were expressed at higher levels in CM. Conclusions. - Increased expression of platelet genes in patients with migraine and CM suggests similar underlying pathophysiology. The differences seen between migraine and CM in other genes suggest an overlapping but not identical pathophysiology. Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis.

Original languageEnglish (US)
Pages (from-to)994-1004
Number of pages11
JournalHeadache
Volume44
Issue number10
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Migraine Disorders
Blood Platelets
Gene Expression
Blood Cells
Overlapping Genes
Immediate-Early Genes
Mitochondrial Genes

Keywords

  • Adolescent
  • Chronic daily headache
  • Headache
  • Immediate early genes
  • Mitochondrial
  • Pediatric

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Genomic abnormalities in patients with migraine and chronic migraine : Preliminary blood gene expression suggests platelet abnormalities. / Hershey, Andrew D.; Tang, Yang; Powers, Scott W.; Kabbouche, Marielle A.; Gilbert, Donald L.; Glauser, Tracy A.; Sharp, Frank R.

In: Headache, Vol. 44, No. 10, 11.2004, p. 994-1004.

Research output: Contribution to journalArticle

Hershey, Andrew D. ; Tang, Yang ; Powers, Scott W. ; Kabbouche, Marielle A. ; Gilbert, Donald L. ; Glauser, Tracy A. ; Sharp, Frank R. / Genomic abnormalities in patients with migraine and chronic migraine : Preliminary blood gene expression suggests platelet abnormalities. In: Headache. 2004 ; Vol. 44, No. 10. pp. 994-1004.
@article{71433e72768c493585763628d4a8a832,
title = "Genomic abnormalities in patients with migraine and chronic migraine: Preliminary blood gene expression suggests platelet abnormalities",
abstract = "Background. - Migraine has strong genetic and environmental components and may also be a significant contributor to chronic migraine (CM). It is hypothesized that gene expression changes in peripheral blood cells can be used to detect the interaction of these influences. Objective. - Distinct genomic expression patterns for migraine and CM will be present. These genomic profiles will help clarify the interactions of inheritance and environment. This initial study begins to examine the feasibility of peripheral blood cell genomic analysis to assist in the understanding of the pathophysiology of migraine and CM. Methods. - Blood samples from patients were obtained either during an acute migraine or CM. Genomic expression patterns were analyzed using Affymetrix U95A microarrays. Results. - Expression patterns of 7 migraine and 15 CM patients were compared to four distinct control groups (total patients, n = 56) including healthy subjects. A group of platelet genes were upregulated in both migraine and CM samples. Different gene expression patterns were also seen between migraine and CM. A group of immediate early genes including c-fos and cox-2 were expressed at higher levels in migraine, whereas specific mitochondrial genes were expressed at higher levels in CM. Conclusions. - Increased expression of platelet genes in patients with migraine and CM suggests similar underlying pathophysiology. The differences seen between migraine and CM in other genes suggest an overlapping but not identical pathophysiology. Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis.",
keywords = "Adolescent, Chronic daily headache, Headache, Immediate early genes, Mitochondrial, Pediatric",
author = "Hershey, {Andrew D.} and Yang Tang and Powers, {Scott W.} and Kabbouche, {Marielle A.} and Gilbert, {Donald L.} and Glauser, {Tracy A.} and Sharp, {Frank R}",
year = "2004",
month = "11",
doi = "10.1111/j.1526-4610.2004.04193.x",
language = "English (US)",
volume = "44",
pages = "994--1004",
journal = "Headache",
issn = "0017-8748",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Genomic abnormalities in patients with migraine and chronic migraine

T2 - Preliminary blood gene expression suggests platelet abnormalities

AU - Hershey, Andrew D.

AU - Tang, Yang

AU - Powers, Scott W.

AU - Kabbouche, Marielle A.

AU - Gilbert, Donald L.

AU - Glauser, Tracy A.

AU - Sharp, Frank R

PY - 2004/11

Y1 - 2004/11

N2 - Background. - Migraine has strong genetic and environmental components and may also be a significant contributor to chronic migraine (CM). It is hypothesized that gene expression changes in peripheral blood cells can be used to detect the interaction of these influences. Objective. - Distinct genomic expression patterns for migraine and CM will be present. These genomic profiles will help clarify the interactions of inheritance and environment. This initial study begins to examine the feasibility of peripheral blood cell genomic analysis to assist in the understanding of the pathophysiology of migraine and CM. Methods. - Blood samples from patients were obtained either during an acute migraine or CM. Genomic expression patterns were analyzed using Affymetrix U95A microarrays. Results. - Expression patterns of 7 migraine and 15 CM patients were compared to four distinct control groups (total patients, n = 56) including healthy subjects. A group of platelet genes were upregulated in both migraine and CM samples. Different gene expression patterns were also seen between migraine and CM. A group of immediate early genes including c-fos and cox-2 were expressed at higher levels in migraine, whereas specific mitochondrial genes were expressed at higher levels in CM. Conclusions. - Increased expression of platelet genes in patients with migraine and CM suggests similar underlying pathophysiology. The differences seen between migraine and CM in other genes suggest an overlapping but not identical pathophysiology. Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis.

AB - Background. - Migraine has strong genetic and environmental components and may also be a significant contributor to chronic migraine (CM). It is hypothesized that gene expression changes in peripheral blood cells can be used to detect the interaction of these influences. Objective. - Distinct genomic expression patterns for migraine and CM will be present. These genomic profiles will help clarify the interactions of inheritance and environment. This initial study begins to examine the feasibility of peripheral blood cell genomic analysis to assist in the understanding of the pathophysiology of migraine and CM. Methods. - Blood samples from patients were obtained either during an acute migraine or CM. Genomic expression patterns were analyzed using Affymetrix U95A microarrays. Results. - Expression patterns of 7 migraine and 15 CM patients were compared to four distinct control groups (total patients, n = 56) including healthy subjects. A group of platelet genes were upregulated in both migraine and CM samples. Different gene expression patterns were also seen between migraine and CM. A group of immediate early genes including c-fos and cox-2 were expressed at higher levels in migraine, whereas specific mitochondrial genes were expressed at higher levels in CM. Conclusions. - Increased expression of platelet genes in patients with migraine and CM suggests similar underlying pathophysiology. The differences seen between migraine and CM in other genes suggest an overlapping but not identical pathophysiology. Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis.

KW - Adolescent

KW - Chronic daily headache

KW - Headache

KW - Immediate early genes

KW - Mitochondrial

KW - Pediatric

UR - http://www.scopus.com/inward/record.url?scp=8844241366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8844241366&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4610.2004.04193.x

DO - 10.1111/j.1526-4610.2004.04193.x

M3 - Article

C2 - 15546262

AN - SCOPUS:8844241366

VL - 44

SP - 994

EP - 1004

JO - Headache

JF - Headache

SN - 0017-8748

IS - 10

ER -