Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP-/-)

Vihas T. Vasu; Brad Hobson; Kishorchandra Gohil; Carroll E Cross

doi:10.1016/j.febslet.2007.03.017

Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP^-/-)

Vihas T. Vasu, Brad Hobson, Kishorchandra Gohil, Carroll E Cross

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Alpha-tocopherol transfer protein (ATTP) null mice (ATTP^-/-) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP^-/- are <10% of those in ATTP^+/+ mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP^-/- mice and compared with their ATTP^+/+ littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of ∼13 000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP^-/- as compared to ATTP^+/+ mice. The present data identifies novel classes of AT sensitive genes in heart tissue.

Original language	English (US)
Pages (from-to)	1572-1578
Number of pages	7
Journal	FEBS Letters
Volume	581
Issue number	8
DOIs	https://doi.org/10.1016/j.febslet.2007.03.017
State	Published - Apr 17 2007

Keywords

Alpha-tocopherol
Alpha-tocopherol transfer protein null mice
Gene expression profiling
Heart

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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title = "Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP-/-)",

abstract = "Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP-/- are <10% of those in ATTP+/+ mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP-/- mice and compared with their ATTP+/+ littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of ∼13 000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP-/- as compared to ATTP+/+ mice. The present data identifies novel classes of AT sensitive genes in heart tissue.",

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author = "Vasu, {Vihas T.} and Brad Hobson and Kishorchandra Gohil and Cross, {Carroll E}",

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AU - Cross, Carroll E

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