Abstract
Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP-/- are <10% of those in ATTP+/+ mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP-/- mice and compared with their ATTP+/+ littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of ∼13 000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP-/- as compared to ATTP+/+ mice. The present data identifies novel classes of AT sensitive genes in heart tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1572-1578 |
| Number of pages | 7 |
| Journal | FEBS Letters |
| Volume | 581 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 17 2007 |
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Keywords
- Alpha-tocopherol
- Alpha-tocopherol transfer protein null mice
- Gene expression profiling
- Heart
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP-/-). / Vasu, Vihas T.; Hobson, Brad; Gohil, Kishorchandra; Cross, Carroll E.
In: FEBS Letters, Vol. 581, No. 8, 17.04.2007, p. 1572-1578.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP-/-)
AU - Vasu, Vihas T.
AU - Hobson, Brad
AU - Gohil, Kishorchandra
AU - Cross, Carroll E
PY - 2007/4/17
Y1 - 2007/4/17
N2 - Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP-/- are <10% of those in ATTP+/+ mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP-/- mice and compared with their ATTP+/+ littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of ∼13 000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP-/- as compared to ATTP+/+ mice. The present data identifies novel classes of AT sensitive genes in heart tissue.
AB - Alpha-tocopherol transfer protein (ATTP) null mice (ATTP-/-) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP-/- are <10% of those in ATTP+/+ mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP-/- mice and compared with their ATTP+/+ littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of ∼13 000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP-/- as compared to ATTP+/+ mice. The present data identifies novel classes of AT sensitive genes in heart tissue.
KW - Alpha-tocopherol
KW - Alpha-tocopherol transfer protein null mice
KW - Gene expression profiling
KW - Heart
UR - http://www.scopus.com/inward/record.url?scp=34047270886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047270886&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2007.03.017
DO - 10.1016/j.febslet.2007.03.017
M3 - Article
C2 - 17382327
AN - SCOPUS:34047270886
VL - 581
SP - 1572
EP - 1578
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 8
ER -