Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu; Pietro Invernizzi; Yue Lu; Roman Kosoy; Yan Lu; Ilaria Bianchi; Mauro Podda; Chun Xu; Gang Xie; Fabio MacCiardi; Carlo Selmi; Sara Lupoli; Russell Shigeta; Michael Ransom; Ana Lleo; Annette T. Lee; Andrew L. Mason; Robert P. Myers; Kevork M. Peltekian; Cameron N. Ghent; Francesca Bernuzzi; Massimo Zuin; Floriano Rosina; Elisabetta Borghesio; Annarosa Floreani; Roberta Lazzari; Grazia Niro; Angelo Andriulli; Luigi Muratori; Paolo Muratori; Piero L. Almasio; Pietro Andreone; Marzia Margotti; Maurizia Brunetto; Barbara Coco; Domenico Alvaro; Maria C. Bragazzi; Fabio Marra; Alessandro Pisano; Cristina Rigamonti; Massimo Colombo; Marco Marzioni; Antonio Benedetti; Luca Fabris; Mario Strazzabosco; Piero Portincasa; Vincenzo O. Palmieri; Claudio Tiribelli; Lory Croce; Savino Bruno; Sonia Rossi; Maria Vinci; Cleofe Prisco; Alberto Mattalia; Pierluigi Toniutto; Antonio Picciotto; Andrea Galli; Carlo Ferrari; Silvia Colombo; Giovanni Casella; Lorenzo Morini; Nicola Caporaso; Agostino Colli; Giancarlo Spinzi; Renzo Montanari; Peter K. Gregersen; E. Jenny Heathcote; Gideon M. Hirschfield; Katherine A. Siminovitch; Christopher I. Amos; M. Eric Gershwin; Michael F Seldin

doi:10.1038/ng.627

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu, Pietro Invernizzi, Yue Lu, Roman Kosoy, Yan Lu, Ilaria Bianchi, Mauro Podda, Chun Xu, Gang Xie, Fabio MacCiardi, Carlo Selmi, Sara Lupoli, Russell Shigeta, Michael Ransom, Ana Lleo, Annette T. Lee, Andrew L. Mason, Robert P. Myers, Kevork M. Peltekian, Cameron N. GhentFrancesca Bernuzzi, Massimo Zuin, Floriano Rosina, Elisabetta Borghesio, Annarosa Floreani, Roberta Lazzari, Grazia Niro, Angelo Andriulli, Luigi Muratori, Paolo Muratori, Piero L. Almasio, Pietro Andreone, Marzia Margotti, Maurizia Brunetto, Barbara Coco, Domenico Alvaro, Maria C. Bragazzi, Fabio Marra, Alessandro Pisano, Cristina Rigamonti, Massimo Colombo, Marco Marzioni, Antonio Benedetti, Luca Fabris, Mario Strazzabosco, Piero Portincasa, Vincenzo O. Palmieri, Claudio Tiribelli, Lory Croce, Savino Bruno, Sonia Rossi, Maria Vinci, Cleofe Prisco, Alberto Mattalia, Pierluigi Toniutto, Antonio Picciotto, Andrea Galli, Carlo Ferrari, Silvia Colombo, Giovanni Casella, Lorenzo Morini, Nicola Caporaso, Agostino Colli, Giancarlo Spinzi, Renzo Montanari, Peter K. Gregersen, E. Jenny Heathcote, Gideon M. Hirschfield, Katherine A. Siminovitch, Christopher I. Amos, M. Eric Gershwin, Michael F Seldin

Research output: Contribution to journal › Article › peer-review

293 Scopus citations

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10^-11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10 ^-10, OR = 1.63) and 17q12-21 (P = 1.7 × 10^-10, OR = 1.38).

Original language	English (US)
Pages (from-to)	658-660
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	8
DOIs	https://doi.org/10.1038/ng.627
State	Published - Aug 2010

ASJC Scopus subject areas

Genetics

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Liu, X., Invernizzi, P., Lu, Y., Kosoy, R., Lu, Y., Bianchi, I., Podda, M., Xu, C., Xie, G., MacCiardi, F., Selmi, C., Lupoli, S., Shigeta, R., Ransom, M., Lleo, A., Lee, A. T., Mason, A. L., Myers, R. P., Peltekian, K. M., ... Seldin, M. F. (2010). Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature Genetics, 42(8), 658-660. https://doi.org/10.1038/ng.627

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. / Liu, Xiangdong; Invernizzi, Pietro; Lu, Yue; Kosoy, Roman; Lu, Yan; Bianchi, Ilaria; Podda, Mauro; Xu, Chun; Xie, Gang; MacCiardi, Fabio; Selmi, Carlo; Lupoli, Sara; Shigeta, Russell; Ransom, Michael; Lleo, Ana; Lee, Annette T.; Mason, Andrew L.; Myers, Robert P.; Peltekian, Kevork M.; Ghent, Cameron N.; Bernuzzi, Francesca; Zuin, Massimo; Rosina, Floriano; Borghesio, Elisabetta; Floreani, Annarosa; Lazzari, Roberta; Niro, Grazia; Andriulli, Angelo; Muratori, Luigi; Muratori, Paolo; Almasio, Piero L.; Andreone, Pietro; Margotti, Marzia; Brunetto, Maurizia; Coco, Barbara; Alvaro, Domenico; Bragazzi, Maria C.; Marra, Fabio; Pisano, Alessandro; Rigamonti, Cristina; Colombo, Massimo; Marzioni, Marco; Benedetti, Antonio; Fabris, Luca; Strazzabosco, Mario; Portincasa, Piero; Palmieri, Vincenzo O.; Tiribelli, Claudio; Croce, Lory; Bruno, Savino; Rossi, Sonia; Vinci, Maria; Prisco, Cleofe; Mattalia, Alberto; Toniutto, Pierluigi; Picciotto, Antonio; Galli, Andrea; Ferrari, Carlo; Colombo, Silvia; Casella, Giovanni; Morini, Lorenzo; Caporaso, Nicola; Colli, Agostino; Spinzi, Giancarlo; Montanari, Renzo; Gregersen, Peter K.; Heathcote, E. Jenny; Hirschfield, Gideon M.; Siminovitch, Katherine A.; Amos, Christopher I.; Gershwin, M. Eric ; Seldin, Michael F.

In: Nature Genetics, Vol. 42, No. 8, 08.2010, p. 658-660.

Research output: Contribution to journal › Article › peer-review

Liu, X, Invernizzi, P, Lu, Y, Kosoy, R, Lu, Y, Bianchi, I, Podda, M, Xu, C, Xie, G, MacCiardi, F, Selmi, C, Lupoli, S, Shigeta, R, Ransom, M, Lleo, A, Lee, AT, Mason, AL, Myers, RP, Peltekian, KM, Ghent, CN, Bernuzzi, F, Zuin, M, Rosina, F, Borghesio, E, Floreani, A, Lazzari, R, Niro, G, Andriulli, A, Muratori, L, Muratori, P, Almasio, PL, Andreone, P, Margotti, M, Brunetto, M, Coco, B, Alvaro, D, Bragazzi, MC, Marra, F, Pisano, A, Rigamonti, C, Colombo, M, Marzioni, M, Benedetti, A, Fabris, L, Strazzabosco, M, Portincasa, P, Palmieri, VO, Tiribelli, C, Croce, L, Bruno, S, Rossi, S, Vinci, M, Prisco, C, Mattalia, A, Toniutto, P, Picciotto, A, Galli, A, Ferrari, C, Colombo, S, Casella, G, Morini, L, Caporaso, N, Colli, A, Spinzi, G, Montanari, R, Gregersen, PK, Heathcote, EJ, Hirschfield, GM, Siminovitch, KA, Amos, CI, Gershwin, ME & Seldin, MF 2010, 'Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis', Nature Genetics, vol. 42, no. 8, pp. 658-660. https://doi.org/10.1038/ng.627

Liu, Xiangdong ; Invernizzi, Pietro ; Lu, Yue ; Kosoy, Roman ; Lu, Yan ; Bianchi, Ilaria ; Podda, Mauro ; Xu, Chun ; Xie, Gang ; MacCiardi, Fabio ; Selmi, Carlo ; Lupoli, Sara ; Shigeta, Russell ; Ransom, Michael ; Lleo, Ana ; Lee, Annette T. ; Mason, Andrew L. ; Myers, Robert P. ; Peltekian, Kevork M. ; Ghent, Cameron N. ; Bernuzzi, Francesca ; Zuin, Massimo ; Rosina, Floriano ; Borghesio, Elisabetta ; Floreani, Annarosa ; Lazzari, Roberta ; Niro, Grazia ; Andriulli, Angelo ; Muratori, Luigi ; Muratori, Paolo ; Almasio, Piero L. ; Andreone, Pietro ; Margotti, Marzia ; Brunetto, Maurizia ; Coco, Barbara ; Alvaro, Domenico ; Bragazzi, Maria C. ; Marra, Fabio ; Pisano, Alessandro ; Rigamonti, Cristina ; Colombo, Massimo ; Marzioni, Marco ; Benedetti, Antonio ; Fabris, Luca ; Strazzabosco, Mario ; Portincasa, Piero ; Palmieri, Vincenzo O. ; Tiribelli, Claudio ; Croce, Lory ; Bruno, Savino ; Rossi, Sonia ; Vinci, Maria ; Prisco, Cleofe ; Mattalia, Alberto ; Toniutto, Pierluigi ; Picciotto, Antonio ; Galli, Andrea ; Ferrari, Carlo ; Colombo, Silvia ; Casella, Giovanni ; Morini, Lorenzo ; Caporaso, Nicola ; Colli, Agostino ; Spinzi, Giancarlo ; Montanari, Renzo ; Gregersen, Peter K. ; Heathcote, E. Jenny ; Hirschfield, Gideon M. ; Siminovitch, Katherine A. ; Amos, Christopher I. ; Gershwin, M. Eric ; Seldin, Michael F. / Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. In: Nature Genetics. 2010 ; Vol. 42, No. 8. pp. 658-660.

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abstract = "A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10-11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10 -10, OR = 1.63) and 17q12-21 (P = 1.7 × 10-10, OR = 1.38).",

author = "Xiangdong Liu and Pietro Invernizzi and Yue Lu and Roman Kosoy and Yan Lu and Ilaria Bianchi and Mauro Podda and Chun Xu and Gang Xie and Fabio MacCiardi and Carlo Selmi and Sara Lupoli and Russell Shigeta and Michael Ransom and Ana Lleo and Lee, {Annette T.} and Mason, {Andrew L.} and Myers, {Robert P.} and Peltekian, {Kevork M.} and Ghent, {Cameron N.} and Francesca Bernuzzi and Massimo Zuin and Floriano Rosina and Elisabetta Borghesio and Annarosa Floreani and Roberta Lazzari and Grazia Niro and Angelo Andriulli and Luigi Muratori and Paolo Muratori and Almasio, {Piero L.} and Pietro Andreone and Marzia Margotti and Maurizia Brunetto and Barbara Coco and Domenico Alvaro and Bragazzi, {Maria C.} and Fabio Marra and Alessandro Pisano and Cristina Rigamonti and Massimo Colombo and Marco Marzioni and Antonio Benedetti and Luca Fabris and Mario Strazzabosco and Piero Portincasa and Palmieri, {Vincenzo O.} and Claudio Tiribelli and Lory Croce and Savino Bruno and Sonia Rossi and Maria Vinci and Cleofe Prisco and Alberto Mattalia and Pierluigi Toniutto and Antonio Picciotto and Andrea Galli and Carlo Ferrari and Silvia Colombo and Giovanni Casella and Lorenzo Morini and Nicola Caporaso and Agostino Colli and Giancarlo Spinzi and Renzo Montanari and Gregersen, {Peter K.} and Heathcote, {E. Jenny} and Hirschfield, {Gideon M.} and Siminovitch, {Katherine A.} and Amos, {Christopher I.} and Gershwin, {M. Eric} and Seldin, {Michael F}",

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