Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes

Hairong Zhu, Jian Wu, Xizhong Shen

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is the third common cause of cancer-related death with highest prevalence in developing countries, such as Southeast China and Saharan African. The major pathogenic factors can be categorized into environmental effects and genetic variations, and it is mostly caused by hepatitis B or C virus (HBV and HCV). The geographic prevalence of chronic hepatitis B and C (CHB and CHC) varies, with HBV heavily-infected in developing countries and HCV prevalent in developed countries. The infection of either hepatitis virus B or C causes damage to the liver cells through cellular immune attack by the mechanism of inflammation. However, how liver cell injury progresses to HCC development is still poorly understood. Along with the maturation of genome-wide association study (GWAS) technology, the specific genetic mutations responsible for the progression from CHB or CHC to HCC have been identified. Moreover, the findings of similar studies for these variants are different from each other due to diverse populations. More functional experiments are warranted to confirm the precise roles of these genetic mutations in the correlations between HBV/HCV and HCC for the future clinical application.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume52
Issue number2
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

Fingerprint

Genome-Wide Association Study
Hepatocellular Carcinoma
Genome
Hepatitis B virus
Hepacivirus
Developing Countries
Mutation
Liver
Chronic Hepatitis B
Chronic Hepatitis C
Developed Countries
China
Inflammation
Technology
Wounds and Injuries
Infection
Population
Neoplasms

Keywords

  • Gene mutation
  • genome-wide association study
  • hepatocellular carcinoma
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Medicine(all)
  • Gastroenterology

Cite this

Genome-wide association study : new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes. / Zhu, Hairong; Wu, Jian; Shen, Xizhong.

In: Scandinavian Journal of Gastroenterology, Vol. 52, No. 2, 01.02.2017, p. 209-215.

Research output: Contribution to journalReview article

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