Abstract
The unique canine breed structure makes dogs an excellent model for studying genetic diseases. Within a dog breed, linkage disequilibrium is extensive, enabling genome-wide association (GWA) with only around 15,000 SNPs and fewer individuals than in human studies. Incidences of specific diseases are elevated in different breeds, indicating that a few genetic risk factors might have accumulated through drift or selective breeding. In this study, a GWA study with 81 affected dogs (cases) and 57 controls from the Nova Scotia duck tolling retriever breed identified five loci associated with a canine systemic lupus erythematosus (SLE)-related disease complex that includes both antinuclear antibody (ANA)-positive immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). Fine mapping with twice as many dogs validated these loci. Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 250-254 |
| Number of pages | 5 |
| Journal | Nature Genetics |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2010 |
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ASJC Scopus subject areas
- Genetics
Cite this
Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. / Wilbe, Maria; Jokinen, Päivi; Truvé, Katarina; Seppala, Eija H.; Karlsson, Elinor K.; Biagi, Tara; Hughes, Angela; Bannasch, Danika L; Andersson, Göran; Hansson-Hamlin, Helene; Lohi, Hannes; Lindblad-Toh, Kerstin.
In: Nature Genetics, Vol. 42, No. 3, 03.2010, p. 250-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex
AU - Wilbe, Maria
AU - Jokinen, Päivi
AU - Truvé, Katarina
AU - Seppala, Eija H.
AU - Karlsson, Elinor K.
AU - Biagi, Tara
AU - Hughes, Angela
AU - Bannasch, Danika L
AU - Andersson, Göran
AU - Hansson-Hamlin, Helene
AU - Lohi, Hannes
AU - Lindblad-Toh, Kerstin
PY - 2010/3
Y1 - 2010/3
N2 - The unique canine breed structure makes dogs an excellent model for studying genetic diseases. Within a dog breed, linkage disequilibrium is extensive, enabling genome-wide association (GWA) with only around 15,000 SNPs and fewer individuals than in human studies. Incidences of specific diseases are elevated in different breeds, indicating that a few genetic risk factors might have accumulated through drift or selective breeding. In this study, a GWA study with 81 affected dogs (cases) and 57 controls from the Nova Scotia duck tolling retriever breed identified five loci associated with a canine systemic lupus erythematosus (SLE)-related disease complex that includes both antinuclear antibody (ANA)-positive immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). Fine mapping with twice as many dogs validated these loci. Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases.
AB - The unique canine breed structure makes dogs an excellent model for studying genetic diseases. Within a dog breed, linkage disequilibrium is extensive, enabling genome-wide association (GWA) with only around 15,000 SNPs and fewer individuals than in human studies. Incidences of specific diseases are elevated in different breeds, indicating that a few genetic risk factors might have accumulated through drift or selective breeding. In this study, a GWA study with 81 affected dogs (cases) and 57 controls from the Nova Scotia duck tolling retriever breed identified five loci associated with a canine systemic lupus erythematosus (SLE)-related disease complex that includes both antinuclear antibody (ANA)-positive immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). Fine mapping with twice as many dogs validated these loci. Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases.
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U2 - 10.1038/ng.525
DO - 10.1038/ng.525
M3 - Article
VL - 42
SP - 250
EP - 254
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 3
ER -