Abstract
The wealth of databases containing genomic information and the easy access via the internet can be an invaluable tool in performing genetic studies and identifying important sequences. This article provides an overview and specific methods for using these resources in both positional cloning and identifying candidate genes for diseases and phenotypes. The ability to apply information across the mouse and human species is stressed. Useful internet sites and their contents are identified and described, and some understanding of their current limitations is provided. As additional genomic definition accelerates, the use of these tools will become more essential in cutting edge research linking sequence and function in whole mammalian organisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 445-457 |
| Number of pages | 13 |
| Journal | Methods: A Companion to Methods in Enzymology |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1997 |
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ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Genome surfing : Using internet-based informatic tools toward functional genetic studies in mouse and humans. / Seldin, Michael F.
In: Methods: A Companion to Methods in Enzymology, Vol. 13, No. 4, 12.1997, p. 445-457.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genome surfing
T2 - Using internet-based informatic tools toward functional genetic studies in mouse and humans
AU - Seldin, Michael F
PY - 1997/12
Y1 - 1997/12
N2 - The wealth of databases containing genomic information and the easy access via the internet can be an invaluable tool in performing genetic studies and identifying important sequences. This article provides an overview and specific methods for using these resources in both positional cloning and identifying candidate genes for diseases and phenotypes. The ability to apply information across the mouse and human species is stressed. Useful internet sites and their contents are identified and described, and some understanding of their current limitations is provided. As additional genomic definition accelerates, the use of these tools will become more essential in cutting edge research linking sequence and function in whole mammalian organisms.
AB - The wealth of databases containing genomic information and the easy access via the internet can be an invaluable tool in performing genetic studies and identifying important sequences. This article provides an overview and specific methods for using these resources in both positional cloning and identifying candidate genes for diseases and phenotypes. The ability to apply information across the mouse and human species is stressed. Useful internet sites and their contents are identified and described, and some understanding of their current limitations is provided. As additional genomic definition accelerates, the use of these tools will become more essential in cutting edge research linking sequence and function in whole mammalian organisms.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031406004&partnerID=8YFLogxK
U2 - 10.1006/meth.1997.0550
DO - 10.1006/meth.1997.0550
M3 - Article
C2 - 9480788
AN - SCOPUS:0031406004
VL - 13
SP - 445
EP - 457
JO - Methods
JF - Methods
SN - 0076-6879
IS - 4
ER -