Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1

Owen White, Jonathan A Eisen, John F. Heidelberg, Erin K. Hickey, Jeremy D. Peterson, Robert J. Dodson, Daniel H. Haft, Michelle L. Gwinn, William C. Nelson, Delwood L. Richardson, Kelly S. Moffat, Haiying Qin, Lingxia Jiang, Wanda Pamphile, Marie Crosby, Mian Shen, Jessica J. Vamathevan, Peter Lam, Lisa McDonald, Terry Utterback & 12 others Celeste Zalewski, Kira S. Makarova, L. Aravind, Michael J. Daly, Kenneth W. Minton, Robert D. Fleischmann, Karen A. Ketchum, Karen E. Nelson, Steven Salzberg, Hamilton O. Smith, J. Craig Venter, Claire M. Fraser

Research output: Contribution to journalArticle

699 Citations (Scopus)

Abstract

The complete genome sequence of the radiation-resistant bacterium Deinococcus radiodurans R1 is composed of two chromosomes (2,648,638 and 412,348 base pairs), a megaplasmid (177,466 base pairs), and a small plasmid (45,704 base pairs), yielding a total genome of 3,284,156 base pairs. Multiple components distributed on the chromosomes and megaplasmid that contribute to the ability of D. radiodurans to survive under conditions of starvation, oxidative stress, and high amounts of DNA damage were identified. Deinococcus radiodurans represents an organism in which all systems for DNA repair, DNA damage export, desiccation and starvation recovery, and genetic redundancy are present in one cell.

Original languageEnglish (US)
Pages (from-to)1571-1577
Number of pages7
JournalScience
Volume286
Issue number5444
DOIs
StatePublished - Nov 19 1999
Externally publishedYes

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Deinococcus
Base Pairing
Genome
Bacteria
Starvation
DNA Damage
Desiccation
Chromosomes, Human, Pair 2
DNA Repair
Oxidative Stress
Plasmids
Chromosomes
Radiation

ASJC Scopus subject areas

  • General

Cite this

White, O., Eisen, J. A., Heidelberg, J. F., Hickey, E. K., Peterson, J. D., Dodson, R. J., ... Fraser, C. M. (1999). Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science, 286(5444), 1571-1577. https://doi.org/10.1126/science.286.5444.1571

Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. / White, Owen; Eisen, Jonathan A; Heidelberg, John F.; Hickey, Erin K.; Peterson, Jeremy D.; Dodson, Robert J.; Haft, Daniel H.; Gwinn, Michelle L.; Nelson, William C.; Richardson, Delwood L.; Moffat, Kelly S.; Qin, Haiying; Jiang, Lingxia; Pamphile, Wanda; Crosby, Marie; Shen, Mian; Vamathevan, Jessica J.; Lam, Peter; McDonald, Lisa; Utterback, Terry; Zalewski, Celeste; Makarova, Kira S.; Aravind, L.; Daly, Michael J.; Minton, Kenneth W.; Fleischmann, Robert D.; Ketchum, Karen A.; Nelson, Karen E.; Salzberg, Steven; Smith, Hamilton O.; Venter, J. Craig; Fraser, Claire M.

In: Science, Vol. 286, No. 5444, 19.11.1999, p. 1571-1577.

Research output: Contribution to journalArticle

White, O, Eisen, JA, Heidelberg, JF, Hickey, EK, Peterson, JD, Dodson, RJ, Haft, DH, Gwinn, ML, Nelson, WC, Richardson, DL, Moffat, KS, Qin, H, Jiang, L, Pamphile, W, Crosby, M, Shen, M, Vamathevan, JJ, Lam, P, McDonald, L, Utterback, T, Zalewski, C, Makarova, KS, Aravind, L, Daly, MJ, Minton, KW, Fleischmann, RD, Ketchum, KA, Nelson, KE, Salzberg, S, Smith, HO, Venter, JC & Fraser, CM 1999, 'Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1', Science, vol. 286, no. 5444, pp. 1571-1577. https://doi.org/10.1126/science.286.5444.1571
White O, Eisen JA, Heidelberg JF, Hickey EK, Peterson JD, Dodson RJ et al. Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science. 1999 Nov 19;286(5444):1571-1577. https://doi.org/10.1126/science.286.5444.1571
White, Owen ; Eisen, Jonathan A ; Heidelberg, John F. ; Hickey, Erin K. ; Peterson, Jeremy D. ; Dodson, Robert J. ; Haft, Daniel H. ; Gwinn, Michelle L. ; Nelson, William C. ; Richardson, Delwood L. ; Moffat, Kelly S. ; Qin, Haiying ; Jiang, Lingxia ; Pamphile, Wanda ; Crosby, Marie ; Shen, Mian ; Vamathevan, Jessica J. ; Lam, Peter ; McDonald, Lisa ; Utterback, Terry ; Zalewski, Celeste ; Makarova, Kira S. ; Aravind, L. ; Daly, Michael J. ; Minton, Kenneth W. ; Fleischmann, Robert D. ; Ketchum, Karen A. ; Nelson, Karen E. ; Salzberg, Steven ; Smith, Hamilton O. ; Venter, J. Craig ; Fraser, Claire M. / Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. In: Science. 1999 ; Vol. 286, No. 5444. pp. 1571-1577.
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