Genome sequence, comparative analysis, and population genetics of the domestic horse

C. M. Wade, E. Giulotto, S. Sigurdsson, M. Zoli, S. Gnerre, F. Imsland, T. L. Lear, D. L. Adelson, E. Bailey, Rebecca Bellone, H. Blöcker, O. Distl, R. C. Edgar, M. Garber, T. Leeb, E. Mauceli, J. N. MacLeod, Cecilia Penedo, J. M. Raison, T. Sharpe & 38 others J. Vogel, L. Andersson, D. F. Antczak, T. Biagi, M. M. Binns, B. P. Chowdhary, S. J. Coleman, G. Della Valle, S. Fryc, G. Guérin, T. Hasegawa, E. W. Hill, J. Jurka, A. Kiialainen, G. Lindgren, J. Liu, E. Magnani, J. R. Mickelson, J. Murray, S. G. Nergadze, R. Onofrio, S. Pedroni, M. F. Piras, T. Raudsepp, M. Rocchi, K. H. Røed, O. A. Ryder, S. Searle, L. Skow, J. E. Swinburne, A. C. Syvänen, T. Tozaki, S. J. Valberg, M. Vaudin, J. R. White, M. C. Zody, E. S. Lander, K. Lindblad-Toh

Research output: Contribution to journalArticle

448 Citations (Scopus)

Abstract

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Original languageEnglish (US)
Pages (from-to)865-867
Number of pages3
JournalScience
Volume326
Issue number5954
DOIs
StatePublished - Nov 6 2009

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Population Genetics
Horses
Sequence Analysis
Genome
Chromosomes
Genomic Segmental Duplications
Satellite DNA
Synteny
Chromosomes, Human, Pair 11
Centromere
Linkage Disequilibrium
Human Chromosomes
Haplotypes
Dogs

ASJC Scopus subject areas

  • General

Cite this

Wade, C. M., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., ... Lindblad-Toh, K. (2009). Genome sequence, comparative analysis, and population genetics of the domestic horse. Science, 326(5954), 865-867. https://doi.org/10.1126/science.1178158

Genome sequence, comparative analysis, and population genetics of the domestic horse. / Wade, C. M.; Giulotto, E.; Sigurdsson, S.; Zoli, M.; Gnerre, S.; Imsland, F.; Lear, T. L.; Adelson, D. L.; Bailey, E.; Bellone, Rebecca; Blöcker, H.; Distl, O.; Edgar, R. C.; Garber, M.; Leeb, T.; Mauceli, E.; MacLeod, J. N.; Penedo, Cecilia; Raison, J. M.; Sharpe, T.; Vogel, J.; Andersson, L.; Antczak, D. F.; Biagi, T.; Binns, M. M.; Chowdhary, B. P.; Coleman, S. J.; Della Valle, G.; Fryc, S.; Guérin, G.; Hasegawa, T.; Hill, E. W.; Jurka, J.; Kiialainen, A.; Lindgren, G.; Liu, J.; Magnani, E.; Mickelson, J. R.; Murray, J.; Nergadze, S. G.; Onofrio, R.; Pedroni, S.; Piras, M. F.; Raudsepp, T.; Rocchi, M.; Røed, K. H.; Ryder, O. A.; Searle, S.; Skow, L.; Swinburne, J. E.; Syvänen, A. C.; Tozaki, T.; Valberg, S. J.; Vaudin, M.; White, J. R.; Zody, M. C.; Lander, E. S.; Lindblad-Toh, K.

In: Science, Vol. 326, No. 5954, 06.11.2009, p. 865-867.

Research output: Contribution to journalArticle

Wade, CM, Giulotto, E, Sigurdsson, S, Zoli, M, Gnerre, S, Imsland, F, Lear, TL, Adelson, DL, Bailey, E, Bellone, R, Blöcker, H, Distl, O, Edgar, RC, Garber, M, Leeb, T, Mauceli, E, MacLeod, JN, Penedo, C, Raison, JM, Sharpe, T, Vogel, J, Andersson, L, Antczak, DF, Biagi, T, Binns, MM, Chowdhary, BP, Coleman, SJ, Della Valle, G, Fryc, S, Guérin, G, Hasegawa, T, Hill, EW, Jurka, J, Kiialainen, A, Lindgren, G, Liu, J, Magnani, E, Mickelson, JR, Murray, J, Nergadze, SG, Onofrio, R, Pedroni, S, Piras, MF, Raudsepp, T, Rocchi, M, Røed, KH, Ryder, OA, Searle, S, Skow, L, Swinburne, JE, Syvänen, AC, Tozaki, T, Valberg, SJ, Vaudin, M, White, JR, Zody, MC, Lander, ES & Lindblad-Toh, K 2009, 'Genome sequence, comparative analysis, and population genetics of the domestic horse', Science, vol. 326, no. 5954, pp. 865-867. https://doi.org/10.1126/science.1178158
Wade CM, Giulotto E, Sigurdsson S, Zoli M, Gnerre S, Imsland F et al. Genome sequence, comparative analysis, and population genetics of the domestic horse. Science. 2009 Nov 6;326(5954):865-867. https://doi.org/10.1126/science.1178158
Wade, C. M. ; Giulotto, E. ; Sigurdsson, S. ; Zoli, M. ; Gnerre, S. ; Imsland, F. ; Lear, T. L. ; Adelson, D. L. ; Bailey, E. ; Bellone, Rebecca ; Blöcker, H. ; Distl, O. ; Edgar, R. C. ; Garber, M. ; Leeb, T. ; Mauceli, E. ; MacLeod, J. N. ; Penedo, Cecilia ; Raison, J. M. ; Sharpe, T. ; Vogel, J. ; Andersson, L. ; Antczak, D. F. ; Biagi, T. ; Binns, M. M. ; Chowdhary, B. P. ; Coleman, S. J. ; Della Valle, G. ; Fryc, S. ; Guérin, G. ; Hasegawa, T. ; Hill, E. W. ; Jurka, J. ; Kiialainen, A. ; Lindgren, G. ; Liu, J. ; Magnani, E. ; Mickelson, J. R. ; Murray, J. ; Nergadze, S. G. ; Onofrio, R. ; Pedroni, S. ; Piras, M. F. ; Raudsepp, T. ; Rocchi, M. ; Røed, K. H. ; Ryder, O. A. ; Searle, S. ; Skow, L. ; Swinburne, J. E. ; Syvänen, A. C. ; Tozaki, T. ; Valberg, S. J. ; Vaudin, M. ; White, J. R. ; Zody, M. C. ; Lander, E. S. ; Lindblad-Toh, K. / Genome sequence, comparative analysis, and population genetics of the domestic horse. In: Science. 2009 ; Vol. 326, No. 5954. pp. 865-867.
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T1 - Genome sequence, comparative analysis, and population genetics of the domestic horse

AU - Wade, C. M.

AU - Giulotto, E.

AU - Sigurdsson, S.

AU - Zoli, M.

AU - Gnerre, S.

AU - Imsland, F.

AU - Lear, T. L.

AU - Adelson, D. L.

AU - Bailey, E.

AU - Bellone, Rebecca

AU - Blöcker, H.

AU - Distl, O.

AU - Edgar, R. C.

AU - Garber, M.

AU - Leeb, T.

AU - Mauceli, E.

AU - MacLeod, J. N.

AU - Penedo, Cecilia

AU - Raison, J. M.

AU - Sharpe, T.

AU - Vogel, J.

AU - Andersson, L.

AU - Antczak, D. F.

AU - Biagi, T.

AU - Binns, M. M.

AU - Chowdhary, B. P.

AU - Coleman, S. J.

AU - Della Valle, G.

AU - Fryc, S.

AU - Guérin, G.

AU - Hasegawa, T.

AU - Hill, E. W.

AU - Jurka, J.

AU - Kiialainen, A.

AU - Lindgren, G.

AU - Liu, J.

AU - Magnani, E.

AU - Mickelson, J. R.

AU - Murray, J.

AU - Nergadze, S. G.

AU - Onofrio, R.

AU - Pedroni, S.

AU - Piras, M. F.

AU - Raudsepp, T.

AU - Rocchi, M.

AU - Røed, K. H.

AU - Ryder, O. A.

AU - Searle, S.

AU - Skow, L.

AU - Swinburne, J. E.

AU - Syvänen, A. C.

AU - Tozaki, T.

AU - Valberg, S. J.

AU - Vaudin, M.

AU - White, J. R.

AU - Zody, M. C.

AU - Lander, E. S.

AU - Lindblad-Toh, K.

PY - 2009/11/6

Y1 - 2009/11/6

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JF - Science

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