Genome sequence, comparative analysis, and population genetics of the domestic horse

C. M. Wade, E. Giulotto, S. Sigurdsson, M. Zoli, S. Gnerre, F. Imsland, T. L. Lear, D. L. Adelson, E. Bailey, Rebecca Bellone, H. Blöcker, O. Distl, R. C. Edgar, M. Garber, T. Leeb, E. Mauceli, J. N. MacLeod, Cecilia Penedo, J. M. Raison, T. SharpeJ. Vogel, L. Andersson, D. F. Antczak, T. Biagi, M. M. Binns, B. P. Chowdhary, S. J. Coleman, G. Della Valle, S. Fryc, G. Guérin, T. Hasegawa, E. W. Hill, J. Jurka, A. Kiialainen, G. Lindgren, J. Liu, E. Magnani, J. R. Mickelson, J. Murray, S. G. Nergadze, R. Onofrio, S. Pedroni, M. F. Piras, T. Raudsepp, M. Rocchi, K. H. Røed, O. A. Ryder, S. Searle, L. Skow, J. E. Swinburne, A. C. Syvänen, T. Tozaki, S. J. Valberg, M. Vaudin, J. R. White, M. C. Zody, E. S. Lander, K. Lindblad-Toh

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494 Scopus citations

Abstract

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

Original languageEnglish (US)
Pages (from-to)865-867
Number of pages3
JournalScience
Volume326
Issue number5954
DOIs
StatePublished - Nov 6 2009

ASJC Scopus subject areas

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    Wade, C. M., Giulotto, E., Sigurdsson, S., Zoli, M., Gnerre, S., Imsland, F., Lear, T. L., Adelson, D. L., Bailey, E., Bellone, R., Blöcker, H., Distl, O., Edgar, R. C., Garber, M., Leeb, T., Mauceli, E., MacLeod, J. N., Penedo, C., Raison, J. M., ... Lindblad-Toh, K. (2009). Genome sequence, comparative analysis, and population genetics of the domestic horse. Science, 326(5954), 865-867. https://doi.org/10.1126/science.1178158