Genome segment reassortment between two serotypes of bluetongue virus in a natural host.

J. L. Stott, R. D. Oberst, M. B. Channell, B. I. Osburn

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62 Citations (Scopus)

Abstract

The occurrence of genome segment reassortment between two antigenically related orbiviruses was demonstrated in cattle. Individual virus clones were isolated by cell culture plaque assays directly from the blood of a calf infected with two serotypes of bluetongue virus. The majority (89%) of progeny viruses isolated from the calf represented reassortant viruses. A minimum of six genome segments participated in reassortment, with 16 unique reassortant constellations being identified. Such genome segment reassortment between unique, though antigenically related, orbiviruses has undoubtedly played a major role in generating the extensive phenotypic and genotypic diversity that is characteristic of this serogroup.

Original languageEnglish (US)
Pages (from-to)2670-2674
Number of pages5
JournalJournal of Virology
Volume61
Issue number9
StatePublished - Sep 1987

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Bluetongue virus
Orbivirus
serotypes
Genome
viruses
genome
Reassortant Viruses
calves
Viruses
cell culture
Clone Cells
Cell Culture Techniques
clones
genetic variation
cattle
blood
assays
Serogroup

ASJC Scopus subject areas

  • Immunology

Cite this

Genome segment reassortment between two serotypes of bluetongue virus in a natural host. / Stott, J. L.; Oberst, R. D.; Channell, M. B.; Osburn, B. I.

In: Journal of Virology, Vol. 61, No. 9, 09.1987, p. 2670-2674.

Research output: Contribution to journalArticle

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