Genome response to tissue plasminogen activator in experimental ischemic stroke

Glen C. Jickling, Xinhua Zhan, Bradley P. Ander, Renée J. Turner, Boryana Stamova, Huichun Xu, Yingfang Tian, Dazhi Liu, Ryan R. Davis, Paul A. Lapchak, Frank R. Sharp

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Tissue plasminogen activator (tPA) is known to have functions beyond fibrinolysis in acute ischemic stroke, such as blood brain barrier disruption. To further delineate tPA functions in the blood, we examined the gene expression profiles induced by tPA in a rat model of ischemic stroke.Results: tPA differentially expressed 929 genes in the blood of rats (p ≤ 0.05, fold change ≥ |1.2|). Genes identified had functions related to modulation of immune cells. tPA gene expression was found to be dependent on the reperfusion status of cerebral vasculature. The majority of genes regulated by tPA were different from genes regulated by ischemic stroke.Conclusions: tPA modulates gene expression in the blood of rats involving immune cells in a manner that is dependent on the status of vascular reperfusion. These non-fibrinolytic activities of tPA in the blood serve to better understand tPA-related complications.

Original languageEnglish (US)
Article number254
JournalBMC Genomics
Volume11
Issue number1
DOIs
StatePublished - Apr 21 2010

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

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