Genome integrity: linking pluripotency and tumorgenicity

Wenbin Deng, Yang Xu

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Genome integrity is a fundamental issue in both cancer and stem cell biology. A series of recent studies revealed that a tumor suppressor p53, which is required for genome integrity, is critical also for stem cell pluripotency and reprogramming, further strengthening the fundamental link between cancer and pluripotency. p53 and other tumor suppressors might be barriers to reprogramming somatic cells for the generation of induced pluripotent stem cells (iPSCs), and simultaneously and systematically destroying these barriers would improve reprogramming efficiency. Therefore, it is also crucial to determine the tumorgenicity of the cells derived from iPSCs for any future therapeutic use.

Original languageEnglish (US)
Pages (from-to)425-427
Number of pages3
JournalTrends in Genetics
Volume25
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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