Vector-borne diseases are responsible for a substantial portion of the global disease. Control of insect vectors is often the best and sometimes the only way to protect the population from these destructive diseases. This chapter reviews vector genetics of three of the most important vector-borne diseases that have much to contribute to understanding vector-borne disease epidemiology and to designing successful control methods. The three diseases are: African sleeping sickness caused by Tsetse Flies, Glossina spp., and African Trypanosomiasis; Chagas disease caused by Triatominae; and malaria caused by Anopheles gambiae. Tsetse flies are obligate blood feeders and the vectors of African trypanosomiasis, caused by trypanosomes that kill humans and domestic mammals. There are no vaccines for human African trypanosomiasis and pharmaceutical treatment is expensive. Current knowledge regarding these species is insufficient. Chagas disease is a zoonosis caused by the flagellate protozoa Trypanosoma cruzi and is restricted to the New World. The Triatominae are the sole vectors. Effective control methods require correct identification of the target population, and genetic studies have been important. Results have contributed to an understanding of the epidemiology of Chagas disease and provided information toward effective control strategies. Malaria control efforts in Africa will have to be conducted on a large geographical scale. Studies of the population genetics of A. gambiae and of vector species in general have resulted in numerous and significant contributions to our understanding of the biology of this group of organisms.
|Original language||English (US)|
|Title of host publication||Genetics and Evolution of Infectious Diseases|
|Number of pages||62|
|State||Published - 2011|
ASJC Scopus subject areas
- Immunology and Microbiology(all)