Genetics of Idiopathic Pulmonary Fibrosis

Andrew Barros, Justin Oldham, Imre Noth

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalAmerican Journal of the Medical Sciences
Volume357
Issue number5
DOIs
StatePublished - May 1 2019

Keywords

  • familial interstitial pneumonia
  • Genetics, Medical
  • Idiopathic pulmonary fibrosis

ASJC Scopus subject areas

  • Medicine(all)

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