Abstract
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 379-383 |
| Number of pages | 5 |
| Journal | American Journal of the Medical Sciences |
| Volume | 357 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2019 |
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Keywords
- familial interstitial pneumonia
- Genetics, Medical
- Idiopathic pulmonary fibrosis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Genetics of Idiopathic Pulmonary Fibrosis. / Barros, Andrew; Oldham, Justin; Noth, Imre.
In: American Journal of the Medical Sciences, Vol. 357, No. 5, 01.05.2019, p. 379-383.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Genetics of Idiopathic Pulmonary Fibrosis
AU - Barros, Andrew
AU - Oldham, Justin
AU - Noth, Imre
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.
AB - Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.
KW - familial interstitial pneumonia
KW - Genetics, Medical
KW - Idiopathic pulmonary fibrosis
UR - http://www.scopus.com/inward/record.url?scp=85063876830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063876830&partnerID=8YFLogxK
U2 - 10.1016/j.amjms.2019.02.009
DO - 10.1016/j.amjms.2019.02.009
M3 - Review article
C2 - 31010464
AN - SCOPUS:85063876830
VL - 357
SP - 379
EP - 383
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 5
ER -