Abstract
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. IPF is a complex disease, with environmental and genetic factors variably contributing to disease susceptibility and outcomes. A host of common gene variants with modest effect size impart disease risk in patients with sporadic IPF, while rare variants with large effect size influence disease risk in those with familial interstitial pneumonia. In this review, we highlight several common and rare variants underpinning IPF risk and call attention to recently published studies informing our understanding of this risk.
Original language | English (US) |
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Pages (from-to) | 379-383 |
Number of pages | 5 |
Journal | American Journal of the Medical Sciences |
Volume | 357 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2019 |
Keywords
- familial interstitial pneumonia
- Genetics, Medical
- Idiopathic pulmonary fibrosis
ASJC Scopus subject areas
- Medicine(all)