Genetics of equine bleeding disorders

Anna R. Dahlgren, Fern Tablin, Carrie J. Finno

Research output: Contribution to journalReview articlepeer-review

Abstract

Genetic bleeding disorders can have a profound impact on a horse's health and athletic career. As such, it is important to understand the mechanisms of these diseases and how they are diagnosed. These diseases include haemophilia A, von Willebrand disease, prekallikrein deficiency, Glanzmann's Thrombasthenia and Atypical Equine Thrombasthenia. Exercise-induced pulmonary haemorrhage also has a proposed genetic component. Genetic mutations have been identified for haemophilia A and Glanzmann's Thrombasthenia in the horse. Mutations are known for von Willebrand disease and prekallikrein deficiency in other species. In the absence of genetic tests, bleeding disorders are typically diagnosed by measuring platelet function, von Willebrand factor, and other coagulation protein levels and activities. For autosomal recessive diseases, genetic testing can prevent the breeding of two carriers.

Original languageEnglish (US)
JournalEquine Veterinary Journal
DOIs
StateAccepted/In press - 2020

Keywords

  • atypical equine thrombasthenia
  • Glanzmann's thrombasthenia
  • haemophilia A
  • horse
  • prekallikrein deficiency
  • von Willebrand disease

ASJC Scopus subject areas

  • Equine

Fingerprint Dive into the research topics of 'Genetics of equine bleeding disorders'. Together they form a unique fingerprint.

Cite this