Genetics and epigenetics of aging and longevity

Alexey A. Moskalev, Alexander M. Aliper, Zeljka McBride, Anton Buzdin, Alex Zhavoronkov

Research output: Contribution to journalReview article

88 Scopus citations

Abstract

Evolutionary theories of aging predict the existence of certain genes that provide selective advantage early in life with adverse effect on lifespan later in life (antagonistic pleiotropy theory) or longevity insurance genes (disposable soma theory). Indeed, the study of human and animal genetics is gradually identifying new genes that increase lifespan when overexpressed or mutated: gerontogenes. Furthermore, genetic and epigenetic mechanisms are being identified that have a positive effect on longevity. The gerontogenes are classified as lifespan regulators, mediators, effectors, housekeeping genes, genes involved in mitochondrial function, and genes regulating cellular senescence and apoptosis. In this review we demonstrate that the majority of the genes as well as genetic and epigenetic mechanisms that are involved in regulation of longevity are highly interconnected and related to stress response.

Original languageEnglish (US)
Pages (from-to)1063-1077
Number of pages15
JournalCell Cycle
Volume13
Issue number7
DOIs
StatePublished - Apr 1 2014

Keywords

  • Aging
  • Epigenetics
  • Evolution
  • Genetics
  • Longevity

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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    Moskalev, A. A., Aliper, A. M., McBride, Z., Buzdin, A., & Zhavoronkov, A. (2014). Genetics and epigenetics of aging and longevity. Cell Cycle, 13(7), 1063-1077. https://doi.org/10.4161/cc.28433