Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk

James Ronald, Ramakrishnan Rajagopalan, Felecia Cerrato, Alexander Nord, Thomas Hatsukami, Ted Kohler, Santica Marcovina, Patrick Heagerty, Gail P. Jarvik

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background and Purpose-Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. Methods-We genotyped single nucleotide polymorphisms (SNPs) in the LPAL2, LPA, and PLG regions in 530 individuals with severe CAAD and 770 controls and kringle IV type 2 (KIV2) repeat length in a subset of 90 individuals. Results-Nine SNPs collectively accounted for 30% of the variance in Lp(a) level. Six SNPs were associated with Lp(a) level after accounting for KIV2 copy number, and the dominant KIV2 allele combined with these markers explained 60% of the variance in Lp(a) level. Five SNPs, including rs10455872, which had an odds ratio of 2.1 per minor allele and haplotypes formed by rs10455872, rs6919346, and rs3123629, were significant predictors of CAAD. After accounting for Lp(a) level, all evidence of CAAD-genotype association in the LPA region was eliminated. Conclusions-LPA region SNPs capture some but not all of the effect of KIV2 repeat length on Lp(a) level. There are associations between LPA region SNPs and CAAD that appear to be attributable to effects on Lp(a) level.

Original languageEnglish (US)
Pages (from-to)2-9
Number of pages8
JournalStroke
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Lipoprotein(a)
Carotid Artery Diseases
Kringles
Single Nucleotide Polymorphism
Alleles
Haplotypes
Coronary Artery Disease
Odds Ratio
Genotype
Genes

Keywords

  • Atherosclerosis
  • Carotid stenosis
  • Genomics
  • Lipoprotein(a)
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk. / Ronald, James; Rajagopalan, Ramakrishnan; Cerrato, Felecia; Nord, Alexander; Hatsukami, Thomas; Kohler, Ted; Marcovina, Santica; Heagerty, Patrick; Jarvik, Gail P.

In: Stroke, Vol. 42, No. 1, 01.01.2011, p. 2-9.

Research output: Contribution to journalArticle

Ronald, J, Rajagopalan, R, Cerrato, F, Nord, A, Hatsukami, T, Kohler, T, Marcovina, S, Heagerty, P & Jarvik, GP 2011, 'Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk', Stroke, vol. 42, no. 1, pp. 2-9. https://doi.org/10.1161/STROKEAHA.110.591230
Ronald, James ; Rajagopalan, Ramakrishnan ; Cerrato, Felecia ; Nord, Alexander ; Hatsukami, Thomas ; Kohler, Ted ; Marcovina, Santica ; Heagerty, Patrick ; Jarvik, Gail P. / Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk. In: Stroke. 2011 ; Vol. 42, No. 1. pp. 2-9.
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AU - Ronald, James

AU - Rajagopalan, Ramakrishnan

AU - Cerrato, Felecia

AU - Nord, Alexander

AU - Hatsukami, Thomas

AU - Kohler, Ted

AU - Marcovina, Santica

AU - Heagerty, Patrick

AU - Jarvik, Gail P.

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N2 - Background and Purpose-Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. Methods-We genotyped single nucleotide polymorphisms (SNPs) in the LPAL2, LPA, and PLG regions in 530 individuals with severe CAAD and 770 controls and kringle IV type 2 (KIV2) repeat length in a subset of 90 individuals. Results-Nine SNPs collectively accounted for 30% of the variance in Lp(a) level. Six SNPs were associated with Lp(a) level after accounting for KIV2 copy number, and the dominant KIV2 allele combined with these markers explained 60% of the variance in Lp(a) level. Five SNPs, including rs10455872, which had an odds ratio of 2.1 per minor allele and haplotypes formed by rs10455872, rs6919346, and rs3123629, were significant predictors of CAAD. After accounting for Lp(a) level, all evidence of CAAD-genotype association in the LPA region was eliminated. Conclusions-LPA region SNPs capture some but not all of the effect of KIV2 repeat length on Lp(a) level. There are associations between LPA region SNPs and CAAD that appear to be attributable to effects on Lp(a) level.

AB - Background and Purpose-Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown. Methods-We genotyped single nucleotide polymorphisms (SNPs) in the LPAL2, LPA, and PLG regions in 530 individuals with severe CAAD and 770 controls and kringle IV type 2 (KIV2) repeat length in a subset of 90 individuals. Results-Nine SNPs collectively accounted for 30% of the variance in Lp(a) level. Six SNPs were associated with Lp(a) level after accounting for KIV2 copy number, and the dominant KIV2 allele combined with these markers explained 60% of the variance in Lp(a) level. Five SNPs, including rs10455872, which had an odds ratio of 2.1 per minor allele and haplotypes formed by rs10455872, rs6919346, and rs3123629, were significant predictors of CAAD. After accounting for Lp(a) level, all evidence of CAAD-genotype association in the LPA region was eliminated. Conclusions-LPA region SNPs capture some but not all of the effect of KIV2 repeat length on Lp(a) level. There are associations between LPA region SNPs and CAAD that appear to be attributable to effects on Lp(a) level.

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