Genetic variability of smoking persistence in African Americans

Ajna Hamidovic, John L. Kasberger, Taylor R. Young, Robert J. Goodloe, Susan Redline, Sarah G. Buxbaum, Neal L. Benowitz, Andrew W. Bergen, Kenneth R. Butler, Nora Franceschini, Sina A. Gharib, Brian Hitsman, Daniel Levy, Yan Meng, George J. Papanicolaou, Sarah R. Preis, Bonnie Spring, Mindi A. Styn, Elisa Tong, Wendy B. WhiteKerri L. Wiggins, Eric Jorgenson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To date, most genetic association analyses of smoking behaviors have been conducted in populations of European ancestry and many of these studies focused on the phenotype that measures smoking quantity, that is, cigarettes per day. Additional association studies in diverse populations with different linkage disequilibrium patterns and an alternate phenotype, such as total tobacco exposure which accounts for intermittent periods of smoking cessation within a larger smoking period as measured in large cardiovascular risk studies, can aid the search for variants relevant to smoking behavior. For these reasons, we undertook an association analysis by using a genotyping array that includes 2,100 genes to analyze smoking persistence in unrelated African American participants from the Atherosclerosis Risk in Communities study. A locus located approximately 4 kb downstream from the 3′-UTR of the brain-derived neurotrophic factor (BDNF) significantly influenced smoking persistence. In addition, independent variants rs12915366 and rs12914385 in the cluster of genes encoding nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4) on 15q25.1 were also associated with the phenotype in this sample of African American subjects. To our knowledge, this is the first study to more extensively evaluate the genome in the African American population, as a limited number of previous studies of smoking behavior in this population included evaluations of only single genomic regions.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalCancer Prevention Research
Volume4
Issue number5
DOIs
StatePublished - May 2011

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African Americans
Smoking
Phenotype
Population
Brain-Derived Neurotrophic Factor
Linkage Disequilibrium
Nicotinic Receptors
3' Untranslated Regions
Smoking Cessation
Multigene Family
Tobacco Products
Tobacco
Atherosclerosis
Genome
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hamidovic, A., Kasberger, J. L., Young, T. R., Goodloe, R. J., Redline, S., Buxbaum, S. G., ... Jorgenson, E. (2011). Genetic variability of smoking persistence in African Americans. Cancer Prevention Research, 4(5), 729-734. https://doi.org/10.1158/1940-6207.CAPR-10-0362

Genetic variability of smoking persistence in African Americans. / Hamidovic, Ajna; Kasberger, John L.; Young, Taylor R.; Goodloe, Robert J.; Redline, Susan; Buxbaum, Sarah G.; Benowitz, Neal L.; Bergen, Andrew W.; Butler, Kenneth R.; Franceschini, Nora; Gharib, Sina A.; Hitsman, Brian; Levy, Daniel; Meng, Yan; Papanicolaou, George J.; Preis, Sarah R.; Spring, Bonnie; Styn, Mindi A.; Tong, Elisa; White, Wendy B.; Wiggins, Kerri L.; Jorgenson, Eric.

In: Cancer Prevention Research, Vol. 4, No. 5, 05.2011, p. 729-734.

Research output: Contribution to journalArticle

Hamidovic, A, Kasberger, JL, Young, TR, Goodloe, RJ, Redline, S, Buxbaum, SG, Benowitz, NL, Bergen, AW, Butler, KR, Franceschini, N, Gharib, SA, Hitsman, B, Levy, D, Meng, Y, Papanicolaou, GJ, Preis, SR, Spring, B, Styn, MA, Tong, E, White, WB, Wiggins, KL & Jorgenson, E 2011, 'Genetic variability of smoking persistence in African Americans', Cancer Prevention Research, vol. 4, no. 5, pp. 729-734. https://doi.org/10.1158/1940-6207.CAPR-10-0362
Hamidovic A, Kasberger JL, Young TR, Goodloe RJ, Redline S, Buxbaum SG et al. Genetic variability of smoking persistence in African Americans. Cancer Prevention Research. 2011 May;4(5):729-734. https://doi.org/10.1158/1940-6207.CAPR-10-0362
Hamidovic, Ajna ; Kasberger, John L. ; Young, Taylor R. ; Goodloe, Robert J. ; Redline, Susan ; Buxbaum, Sarah G. ; Benowitz, Neal L. ; Bergen, Andrew W. ; Butler, Kenneth R. ; Franceschini, Nora ; Gharib, Sina A. ; Hitsman, Brian ; Levy, Daniel ; Meng, Yan ; Papanicolaou, George J. ; Preis, Sarah R. ; Spring, Bonnie ; Styn, Mindi A. ; Tong, Elisa ; White, Wendy B. ; Wiggins, Kerri L. ; Jorgenson, Eric. / Genetic variability of smoking persistence in African Americans. In: Cancer Prevention Research. 2011 ; Vol. 4, No. 5. pp. 729-734.
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