Genetic susceptibility to feline infectious peritonitis in Birman cats

Lyudmila Golovko, Leslie A Lyons, Hongwei Liu, Anne Sørensen, Suzanne Wehnert, Niels C Pedersen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Genetic factors are presumed to influence the incidence of feline infectious peritonitis (FIP), especially among pedigreed cats. However, proof for the existence of such factors has been limited and mainly anecdotal. Therefore, we sought evidence for genetic susceptibility to FIP using feline high density single nucleotide polymorphism (SNP) arrays in a genome-wide association study (GWAS). Birman cats were chosen for GWAS because they are highly inbred and suffer a high incidence of FIP. DNA from 38 Birman cats that died of FIP and 161 healthy cats from breeders in Denmark and USA were selected for genotyping using 63K SNPs distributed across the feline genome. Danish and American Birman cats were closely related and the populations were therefore combined and analyzed in two manners: (1) all cases (FIP) vs. all controls (healthy) regardless of age, and (2) cases 11/2 years of age and younger (most susceptible) vs. controls 2 years of age and older (most resistant). GWAS of the second cohort was most productive in identifying significant genome-wide associations between case and control cats. Four peaks of association with FIP susceptibility were identified, with two being identified on both analyses. Five candidate genes ELMO1, RRAGA, TNFSF10, ERAP1 and ERAP2, all relevant to what is known about FIP virus pathogenesis, were identified but no single association was fully concordant with the disease phenotype. Difficulties in doing GWAS in cats and interrogating complex genetic traits were discussed.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalVirus Research
Volume175
Issue number1
DOIs
StatePublished - Jul 2013

Fingerprint

Feline Infectious Peritonitis
Genetic Predisposition to Disease
Cats
Genome-Wide Association Study
Felidae
Single Nucleotide Polymorphism
Feline Coronavirus
Genome
Incidence
Denmark
Phenotype

Keywords

  • Birman cats
  • Feline infectious peritonitis
  • Genetics
  • Susceptibility

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Cancer Research

Cite this

Genetic susceptibility to feline infectious peritonitis in Birman cats. / Golovko, Lyudmila; Lyons, Leslie A; Liu, Hongwei; Sørensen, Anne; Wehnert, Suzanne; Pedersen, Niels C.

In: Virus Research, Vol. 175, No. 1, 07.2013, p. 58-63.

Research output: Contribution to journalArticle

Golovko, Lyudmila ; Lyons, Leslie A ; Liu, Hongwei ; Sørensen, Anne ; Wehnert, Suzanne ; Pedersen, Niels C. / Genetic susceptibility to feline infectious peritonitis in Birman cats. In: Virus Research. 2013 ; Vol. 175, No. 1. pp. 58-63.
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