Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans

Klodian Dhana, Lisa L. Barnes, Xiaoran Liu, Puja Agarwal, Pankaja Desai, Kristin R. Krueger, Thomas M. Holland, Shannon Halloway, Neelum T. Aggarwal, Denis A. Evans, Kumar B. Rajan

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans. Methods: Using data from the Chicago Health and Aging Project (1993–2012; n = 3874), we defined the genetic risk based on presence of apolipoprotein E (APOE) (Formula presented.) allele and determined a healthy lifestyle using a scoring of five factors: non-smoking, exercising, being cognitively active, having a high-quality diet, and limiting alcohol use. We used linear mixed-effects models to estimate cognitive decline by genetic risk and lifestyle score. Results: APOE (Formula presented.) allele was associated with faster cognitive decline in both races. However, within APOE (Formula presented.) carriers, adherence to a healthy lifestyle (eg., 4 to 5 healthy factors) was associated with a slower cognitive decline by 0.023 (95% confidence interval [CI] 0.004, 0.042) units/year in African Americans and 0.044 (95% CI 0.008, 0.080) units/year in European Americans. Discussion: A healthy lifestyle was associated with a slower cognitive decline in African and European Americans.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • African Americans
  • apolipoprotein E
  • cognitive decline
  • European Americans
  • genetic epidemiology
  • lifestyle factors
  • race/ethnicity

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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