Abstract
The segregation of Mlsa with respect to genes localized distally on mouse chromosome 1 was examined in two sets of recombinant inbred (RI) strains. In order to localize Mlsa, a linkage map based on analysis of both interspecific backcross mice and multiple sets of RI strains was utilized: (centromere) - Ren-1,2 - 10 centimorgans (cM) - At-3 - 8cM-Apo-A2/Ly-17 - 2 cM - Spna-1 - 4 cM - Akp-1 - (telomere). The Mlsa allele was mapped to a region that extended just centromeric of Ly-17 (one crossover in 40 RI strains) to just telomeric of Spna-1 (no crossover in 40 RI strains). The indentification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-66 |
| Number of pages | 8 |
| Journal | Journal of Immunogenetics |
| Volume | 15 |
| Issue number | 1-3 |
| State | Published - 1988 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Immunology
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Seldin, M. F., Abe, R., Steinberg, A. D., Hodes, R. J., & Morse, H. C. (1988). Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1. Journal of Immunogenetics, 15(1-3), 59-66.