Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1

Michael F Seldin, R. Abe, A. D. Steinberg, R. J. Hodes, H. C. Morse

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The segregation of Mlsa with respect to genes localized distally on mouse chromosome 1 was examined in two sets of recombinant inbred (RI) strains. In order to localize Mlsa, a linkage map based on analysis of both interspecific backcross mice and multiple sets of RI strains was utilized: (centromere) - Ren-1,2 - 10 centimorgans (cM) - At-3 - 8cM-Apo-A2/Ly-17 - 2 cM - Spna-1 - 4 cM - Akp-1 - (telomere). The Mlsa allele was mapped to a region that extended just centromeric of Ly-17 (one crossover in 40 RI strains) to just telomeric of Spna-1 (no crossover in 40 RI strains). The indentification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalJournal of Immunogenetics
Issue number1-3
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Immunology


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