Abstract
The segregation of Mlsa with respect to genes localized distally on mouse chromosome 1 was examined in two sets of recombinant inbred (RI) strains. In order to localize Mlsa, a linkage map based on analysis of both interspecific backcross mice and multiple sets of RI strains was utilized: (centromere) - Ren-1,2 - 10 centimorgans (cM) - At-3 - 8cM-Apo-A2/Ly-17 - 2 cM - Spna-1 - 4 cM - Akp-1 - (telomere). The Mlsa allele was mapped to a region that extended just centromeric of Ly-17 (one crossover in 40 RI strains) to just telomeric of Spna-1 (no crossover in 40 RI strains). The indentification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene.
Original language | English (US) |
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Pages (from-to) | 59-66 |
Number of pages | 8 |
Journal | Journal of Immunogenetics |
Volume | 15 |
Issue number | 1-3 |
State | Published - 1988 |
Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Immunology