Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients

Constance L. Monitto, Robert G. Hamilton, Eric Levey, Anne E. Jedlicka, Amanda Dziedzic, John P. Gearhart, Simeon Boyd, Robert H. Brown

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: In health care workers, the natural rubber latex (NRL) allergy phenotype has been shown to be associated with promoter polymorphisms in interleukins 13 and 18 (IL13 and IL18) when compared with nonatopic controls. However, it is not known whether high-risk patient populations, such as those born with neural tube defects or genitourinary abnormalities, demonstrate a heightened propensity toward the same genetic/immunologic risk factors that have been reported for health care workers. In this study, we tested the hypothesis that single-nucleotide polymorphisms in genes encoding IL13 and IL18 occur at an increased frequency in NRL allergic patients with spina bifida (SB) or bladder exstrophy (Be). Methods: One hundred twenty subjects (40 SB, 40 BE, and 40 control) were screened using a clinical history questionnaire and NRL-specific immunoglobulin E (IgE) antibody measurements in the blood. Genomic DNA was extracted from peripheral blood lymphocytes and analyzed for single-nucleotide polymorphisms in candidate genes of interest. Univariate and multivariate analyses were performed to identify significant variables with significance defined as P < 0.05. Results: Sensitization (IgE antibody positivity) to NRL allergens was associated with atopic history and number of prior operations and was prevented by the avoidance of NRL beginning at birth. However, unlike health care workers, the NRL allergy phenotype was not significantly associated with promoter polymorphisms in IL13 or IL18 when comparing NRL allergic SB and BE patients with nonsensitized patients and with atopic and nonatopic controls. Conclusions: In patients born with SB or BE, environmental factors seem to play a greater role in the development of NRL sensitization and overt allergic symptoms than the IL polymorphisms in IL13 and IL18 previously shown to be associated with NRL allergy in health care workers.

Original languageEnglish (US)
Pages (from-to)1310-1317
Number of pages8
JournalAnesthesia and Analgesia
Volume110
Issue number5
DOIs
StatePublished - May 2010

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Latex Hypersensitivity
Rubber
Latex
Genetic Predisposition to Disease
Interleukin-18
Interleukin-13
Spinal Dysraphism
Delivery of Health Care
Immunoglobulin E
Single Nucleotide Polymorphism
Urogenital Abnormalities
Bladder Exstrophy
Phenotype
Neural Tube Defects
Antibodies
Immunologic Factors
Allergens
Genes
Multivariate Analysis
History

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Monitto, C. L., Hamilton, R. G., Levey, E., Jedlicka, A. E., Dziedzic, A., Gearhart, J. P., ... Brown, R. H. (2010). Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients. Anesthesia and Analgesia, 110(5), 1310-1317. https://doi.org/10.1213/ANE.0b013e3181d7e31c

Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients. / Monitto, Constance L.; Hamilton, Robert G.; Levey, Eric; Jedlicka, Anne E.; Dziedzic, Amanda; Gearhart, John P.; Boyd, Simeon; Brown, Robert H.

In: Anesthesia and Analgesia, Vol. 110, No. 5, 05.2010, p. 1310-1317.

Research output: Contribution to journalArticle

Monitto, CL, Hamilton, RG, Levey, E, Jedlicka, AE, Dziedzic, A, Gearhart, JP, Boyd, S & Brown, RH 2010, 'Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients', Anesthesia and Analgesia, vol. 110, no. 5, pp. 1310-1317. https://doi.org/10.1213/ANE.0b013e3181d7e31c
Monitto, Constance L. ; Hamilton, Robert G. ; Levey, Eric ; Jedlicka, Anne E. ; Dziedzic, Amanda ; Gearhart, John P. ; Boyd, Simeon ; Brown, Robert H. / Genetic predisposition to natural rubber latex allergy differs between health care workers and high-risk patients. In: Anesthesia and Analgesia. 2010 ; Vol. 110, No. 5. pp. 1310-1317.
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