Genetic organization of complement receptor-related genes in the mouse

S. F. Kingsmore, D. P. Vik, C. B. Kurtz, P. Leroy, B. F. Tack, J. H. Weis, Michael F Seldin

Research output: Contribution to journalArticle

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Abstract

Using an interspecific cross, gene linkage relationships among members of the murine complement receptor-related genes, C4bp, Cfh, Mcry, and Mcr2, were analyzed by segregation of RFLP in 200 mice. The human homologues of these genes are tightly linked, composing the RCA locus, which maps to human chromosome (Chr.)1q32, within a large linkage group conserved between human Chr.1q21-32 and mouse Chr.1. RFLP associated with C4bp and Cfh map within this conserved linkage group; Cfh is located 9 cM telomeric to C4bp, which is consistent with linkage data for their human homologues. Mcry and Mcr2, while tightly linked, are located outside the conserved group, 40 cM telomeric to C4bp. These data suggest that a translocation or inversion occurred within the RCA family during the evolution of the mouse, defining a breakpoint of this large conserved linkage group.

Original languageEnglish (US)
Pages (from-to)1479-1484
Number of pages6
JournalJournal of Experimental Medicine
Volume169
Issue number4
StatePublished - 1989
Externally publishedYes

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Complement Receptors
Restriction Fragment Length Polymorphisms
Genes
Information Storage and Retrieval
Human Chromosomes

ASJC Scopus subject areas

  • Immunology

Cite this

Kingsmore, S. F., Vik, D. P., Kurtz, C. B., Leroy, P., Tack, B. F., Weis, J. H., & Seldin, M. F. (1989). Genetic organization of complement receptor-related genes in the mouse. Journal of Experimental Medicine, 169(4), 1479-1484.

Genetic organization of complement receptor-related genes in the mouse. / Kingsmore, S. F.; Vik, D. P.; Kurtz, C. B.; Leroy, P.; Tack, B. F.; Weis, J. H.; Seldin, Michael F.

In: Journal of Experimental Medicine, Vol. 169, No. 4, 1989, p. 1479-1484.

Research output: Contribution to journalArticle

Kingsmore, SF, Vik, DP, Kurtz, CB, Leroy, P, Tack, BF, Weis, JH & Seldin, MF 1989, 'Genetic organization of complement receptor-related genes in the mouse', Journal of Experimental Medicine, vol. 169, no. 4, pp. 1479-1484.
Kingsmore SF, Vik DP, Kurtz CB, Leroy P, Tack BF, Weis JH et al. Genetic organization of complement receptor-related genes in the mouse. Journal of Experimental Medicine. 1989;169(4):1479-1484.
Kingsmore, S. F. ; Vik, D. P. ; Kurtz, C. B. ; Leroy, P. ; Tack, B. F. ; Weis, J. H. ; Seldin, Michael F. / Genetic organization of complement receptor-related genes in the mouse. In: Journal of Experimental Medicine. 1989 ; Vol. 169, No. 4. pp. 1479-1484.
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