Genetic mapping and assignment of a long-range repeat cluster to band D of chromosome 1 in Mus musculus and M. spretus

W. Traut, Michael F Seldin, H. Winking

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Abstract

A cluster (D1Lubl) of a long-range repeat family was mapped to the proximal part of the Giemsa-negative band D in Chromosome 1 of Mus musculus and M. spretus by in situ hybridization with cloned probes of the long-range repeat family. By making use of restriction fragment length polymorphisms in DNAs from interspecific backcross mice, the cluster could be mapped to a position 5.3 ± 2.1 cM distal to the Inha locus and the same distance proximal to the Bcl-2 locus. D1Lubl was inseparable in 114 meiotic events from Acrg, Sag, and Akp-3. Taken together, the data may serve as a reference for coordinating the genetic and cytogenetic maps of Mus Chromosome 1. High-copy-number variants of the cluster, which appear cytogenetically as homogeneously staining regions at the same chromosome location, presumably arose by amplification of the long-range repeat family in situ.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalCytogenetics and Cell Genetics
Volume60
Issue number2
StatePublished - 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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