Genetic Diversity and Population Structure of Mycobacterium tuberculosis in Casablanca, a Moroccan City with High Incidence of Tuberculosis

Loubna Rothenburg, Jamila El Baghdadi, Sarah Lesjean, Camille Locht, Philip Supply, Michel Tibayrenc, Anne Laure Bañuls

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Abstract

Although lower-resource countries have by far the highest burden of tuberculosis, knowledge of Mycobacterium tuberculosis population structure and genetic diversity in these regions remains almost nonexistent. In this paper, 150 Moroccan M. tuberculosis isolates circulating in Casablanca were genotyped by random amplified polymorphic DNA analysis using 10 different primers and by mycobacterial interspersed repetitive units-variable number of tandem repeats typing at 12 loci. The population genetic tests revealed a basically clonal structure for this population, without excluding rare genetic exchanges. Genetic analysis also showed a notable genetic polymorphism for the species M. tuberculosis, a weak cluster individualization, and an unexpected genetic diversity for a population in such a high-incidence community. Phylogenetic analyses of this Moroccan sample also supported that these isolates are genetically heterogeneous.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalJournal of Clinical Microbiology
Volume42
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)

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