Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation

Maija Ht Kiuru, Julie L. Boyer, Timothy P. O'Connor, Ronald G. Crystal

Research output: Contribution to journalReview article

60 Scopus citations

Abstract

The proliferative capacity of pluripotent stem cells and their progeny brings a unique aspect to therapeutics, in that once a transplant is initiated the therapist no longer has control of the therapy. In the context of the recent FDA approval of a human ESC trial and report of a neuronal-stem-cell-derived tumor in a human trial, strategies need to be developed to control wayward pluripotent stem cells. Here, we focus on one approach: direct genetic modification of the cells prior to transplantation with genes that can prevent the adverse events and/or eliminate the transplanted cells and their progeny.

Original languageEnglish (US)
Pages (from-to)289-300
Number of pages12
JournalCell Stem Cell
Volume4
Issue number4
DOIs
StatePublished - Apr 3 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

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