Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation

Maija Ht Kiuru; Julie L. Boyer; Timothy P. O'Connor; Ronald G. Crystal

doi:10.1016/j.stem.2009.03.010

Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation

Maija Ht Kiuru, Julie L. Boyer, Timothy P. O'Connor, Ronald G. Crystal

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

The proliferative capacity of pluripotent stem cells and their progeny brings a unique aspect to therapeutics, in that once a transplant is initiated the therapist no longer has control of the therapy. In the context of the recent FDA approval of a human ESC trial and report of a neuronal-stem-cell-derived tumor in a human trial, strategies need to be developed to control wayward pluripotent stem cells. Here, we focus on one approach: direct genetic modification of the cells prior to transplantation with genes that can prevent the adverse events and/or eliminate the transplanted cells and their progeny.

Original language	English (US)
Pages (from-to)	289-300
Number of pages	12
Journal	Cell Stem Cell
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2009.03.010
State	Published - Apr 3 2009
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Medicine
Genetics

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AB - The proliferative capacity of pluripotent stem cells and their progeny brings a unique aspect to therapeutics, in that once a transplant is initiated the therapist no longer has control of the therapy. In the context of the recent FDA approval of a human ESC trial and report of a neuronal-stem-cell-derived tumor in a human trial, strategies need to be developed to control wayward pluripotent stem cells. Here, we focus on one approach: direct genetic modification of the cells prior to transplantation with genes that can prevent the adverse events and/or eliminate the transplanted cells and their progeny.

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Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation

Abstract

ASJC Scopus subject areas

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