Genetic characterization of canine distemper virus in Serengeti carnivores

Margaret A. Carpenter, Max J.g. Appel, Melody E. Roelke-Parker, Linda Munson, Heribert Hofer, Marion East, Stephen J. O'Brien

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

The lion (Panthera leo) population in the Serengeti ecosystem was recently afflicted by a fatal epidemic involving neurological disease, encephalitis and pneumonia. The cause was identified as canine distemper virus (CDV). Several other species in the Serengeti were also affected. This report presents CDV H and P gene sequences isolated from Serengeti lions (Panthera leo), spotted hyenas (Crocuta crocuta), bat-eared fox (Otocyon megalotis) and domestic dog (Canis familiaris). Sequence analyses demonstrated that the four Serengeti species carry closely related CDV isolates which are genetically distinct from other CDV isolates from various species and locations. The results are consistent with the conclusions that: (1) a particularly virulent strain of CDV emerged among Serengeti carnivores within the last few years; (2) that strain has recognizable shared-derived (synapomorphic) genetic differences in both H and P genes when compared to CDV from other parts of the world; and (3) that the CDV strain has frequently crossed host species among Serengeti carnivores.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume65
Issue number2-4
DOIs
StatePublished - Oct 23 1998
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology
  • veterinary(all)

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    Carpenter, M. A., J.g. Appel, M., Roelke-Parker, M. E., Munson, L., Hofer, H., East, M., & O'Brien, S. J. (1998). Genetic characterization of canine distemper virus in Serengeti carnivores. Veterinary Immunology and Immunopathology, 65(2-4), 259-266. https://doi.org/10.1016/S0165-2427(98)00159-7