Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice

Thomas H. Roderick, Richard E. Wimer, Cynthia C. Wimer, Philip A Schwartzkroin

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Mice of both sexes from 25 inbred strains and 1 distantly related stock were studied for their adult brain weight, spinal cord weight, ratio of brain weight to spinal cord weight, and ratio of brain weight to body weight. Females were significantly greater than males for brain weight, spinal cord weight, and ration of brain weight to body weight. Sizeable strain differences were shown for all traits. The largest coefficients of genetic determination were + 0.62 and + 0.67 for brain weight for males and females, respectively. The two ratios, brain weight to spinal cord weight and brain weight to body weight, were quite different for different strains and showed no correlation between strains. This suggests they are different measures and cannot be considered genetically similar. The weights and volumes of brains were highly correlated.

Original languageEnglish (US)
Pages (from-to)345-353
Number of pages9
JournalBrain Research
Volume64
Issue numberC
DOIs
StatePublished - Dec 21 1973
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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