Genetic analysis of multiplex rheumatoid arthritis families

D. Bali, S. Gourley, D. D. Kostyu, N. Goel, I. Bruce, A. Bell, D. J. Walker, K. Tran, D. K. Zhu, T. J. Costello, C. I. Amos, Michael F Seldin

Research output: Contribution to journalArticle

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Abstract

To examine the genetic contribution of HLA and non-HLA genes in the etiopathogenesis of rheumatoid arthritis (RA), 60 Caucasian multiplex families were identified and DNA analyzed for over 52 markers including DRB1, DQA1 and DQB1 alleles. Many of the markers were chosen because of close proximity to candidate genes suggested by previous studies or models of pathogenesis. Sibling pair analysis (SIBPAL), relative pair analysis (RELPAL) and linkage studies using two different models of inheritance suggested linkage for the MHC and two additional chromosomal regions: chromosome 2 (D2S443 near CD8 and IGκ; 2p13-2p11.1), and chromosome 15 (CYP19-estrogen synthase; 15q15). No support was found for two chromosomal regions, 1p36 and 3q13, recently suggested by other studies. We used transmission disequilibrium testing (TDT), conditional logistic regression, and segregation analysis to study the contributions that the shared epitope and TNF-c have in contributing to risk for RA. These studies provide additional evidence that the association of HLA alleles in RA patients from multiplex families is similar to that observed in sporadic disease, suggest candidate regions for further analysis and find additional support for an association of TNF-c alleles with RA susceptibility.

Original languageEnglish (US)
Pages (from-to)28-35
Number of pages8
JournalGenes and Immunity
Volume1
Issue number1
StatePublished - Sep 1999

Fingerprint

Rheumatoid Arthritis
Aromatase
Alleles
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 2
Genes
Siblings
Epitopes
Logistic Models
Regression Analysis
DNA

Keywords

  • Genetics
  • MHC
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Genetics
  • Immunology
  • Genetics(clinical)

Cite this

Bali, D., Gourley, S., Kostyu, D. D., Goel, N., Bruce, I., Bell, A., ... Seldin, M. F. (1999). Genetic analysis of multiplex rheumatoid arthritis families. Genes and Immunity, 1(1), 28-35.

Genetic analysis of multiplex rheumatoid arthritis families. / Bali, D.; Gourley, S.; Kostyu, D. D.; Goel, N.; Bruce, I.; Bell, A.; Walker, D. J.; Tran, K.; Zhu, D. K.; Costello, T. J.; Amos, C. I.; Seldin, Michael F.

In: Genes and Immunity, Vol. 1, No. 1, 09.1999, p. 28-35.

Research output: Contribution to journalArticle

Bali, D, Gourley, S, Kostyu, DD, Goel, N, Bruce, I, Bell, A, Walker, DJ, Tran, K, Zhu, DK, Costello, TJ, Amos, CI & Seldin, MF 1999, 'Genetic analysis of multiplex rheumatoid arthritis families', Genes and Immunity, vol. 1, no. 1, pp. 28-35.
Bali D, Gourley S, Kostyu DD, Goel N, Bruce I, Bell A et al. Genetic analysis of multiplex rheumatoid arthritis families. Genes and Immunity. 1999 Sep;1(1):28-35.
Bali, D. ; Gourley, S. ; Kostyu, D. D. ; Goel, N. ; Bruce, I. ; Bell, A. ; Walker, D. J. ; Tran, K. ; Zhu, D. K. ; Costello, T. J. ; Amos, C. I. ; Seldin, Michael F. / Genetic analysis of multiplex rheumatoid arthritis families. In: Genes and Immunity. 1999 ; Vol. 1, No. 1. pp. 28-35.
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