Genetic advances in craniosynostosis

Wanda Lattanzi, Marta Barba, Lorena Di Pietro, Simeon Boyd

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Craniosynostosis, the premature ossification of one or more skull sutures, is a clinically and genetically heterogeneous congenital anomaly affecting approximately one in 2,500 live births. In most cases, it occurs as an isolated congenital anomaly, that is, nonsyndromic craniosynostosis (NCS), the genetic, and environmental causes of which remain largely unknown. Recent data suggest that, at least some of the midline NCS cases may be explained by two loci inheritance. In approximately 25–30% of patients, craniosynostosis presents as a feature of a genetic syndrome due to chromosomal defects or mutations in genes within interconnected signaling pathways. The aim of this review is to provide a detailed and comprehensive update on the genetic and environmental factors associated with NCS, integrating the scientific findings achieved during the last decade. Focus on the neurodevelopmental, imaging, and treatment aspects of NCS is also provided.

Original languageEnglish (US)
Pages (from-to)1406-1429
Number of pages24
JournalAmerican Journal of Medical Genetics, Part A
Issue number5
StatePublished - May 1 2017


  • craniofacial
  • craniosynostosis
  • gene mutations
  • malformation
  • skull sutures

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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