Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.

R. B. Kent, D. A. Fallows, E. Geissler, Thomas M Glaser, J. R. Emanuel, P. A. Lalley, R. Levenson, D. E. Housman

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

We have made use of a panel of mouse-hamster somatic cell hybrids and restriction fragment length polymorphisms between two mouse species (Mus musculus and Mus spretus) to determine the chromosomal localization of genes encoding the alpha and beta subunits of the Na,K-ATPase (Na+,K+-activated ATP phosphohydrolase, EC 3.6.1.3). DNA probes for three distinct isoforms of the Na,K-ATPase alpha subunit mapped to three different mouse chromosomes: the alpha 1 gene (Atpa-1) cosegregated with the Egf gene on chromosome 3; alpha 2 (Atpa-2) with the cytochrome P-450PB gene family/coumarin hydroxylase locus on chromosome 7; alpha 3 (Atpa-3) with the alpha-spectrin gene on chromosome 1. The Na,K-ATPase beta-subunit gene (Atpb) mapped to the same region of chromosome 1, but it was not tightly linked to the Atpa-3 gene. These results indicate that three isoforms of the Na,K-ATPase alpha subunit are encoded by three distinct genes. The dispersion of Na,K-ATPase genes suggests that their expression is not likely to be controlled by a common cis-acting regulatory element.

Original languageEnglish (US)
Pages (from-to)5369-5373
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume84
Issue number15
StatePublished - Aug 1987
Externally publishedYes

ASJC Scopus subject areas

  • General
  • Genetics

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