Generative modeling for label-free glomerular modeling and classification

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Generative modeling using GANs has gained traction in machine learning literature, as training does not require labeled datasets. This is perfect for applications in biological datasets, where large labeled datasets are often difficult and expensive to acquire. However, generative models offer no easy way to encode real images into feature-sets, something that is desirable for network explainability and may yield potentially informative image features. For this reason, we test a VAE-GAN architecture for label-free modeling of glomerular structural features. We show that this network can generate realistic looking synthetic images, and be used to interpolate between images. To prove the biological relevance of the network encodings, we classify small-labeled sets of encoded glomeruli by biopsy Tervaert class and for the presence of sclerosis, obtaining a Cohen's kappa values of 0.87 and 0.78 respectfully.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2020
Subtitle of host publicationDigital Pathology
EditorsJohn E. Tomaszewski, Aaron D. Ward
PublisherSPIE
ISBN (Electronic)9781510634077
DOIs
StatePublished - 2020
EventMedical Imaging 2020: Digital Pathology - Houston, United States
Duration: Feb 19 2020Feb 20 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11320
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2020: Digital Pathology
Country/TerritoryUnited States
CityHouston
Period2/19/202/20/20

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