Generation of functionally distinct B lymphocytes from common myeloid progenitors

G. X. Yang, Z. X. Lian, Y. H. Chuang, S. A. Shu, Y. Moritoki, R. Lan, K. Wakabayashi, A. A. Ansari, K. Dorshkind, S. Ikehara, M. Eric Gershwin

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Current models of adult haematopoiesis propose that haematopoietic stem cells (HSCs) differentiate into common lymphoid (CLP) and common myeloid (CMP) progenitors and establish an early separation between myeloid and lymphoid lineages. Nevertheless, the developmental potential of CMP-associated B cells suggests the existence of alternate pathways for B lymphopoesis. The aim of this study was to compare the developmental and functional properties of CMP- and CLP-derived B cells. While both populations matured through pro-B cell and transitional B cell intermediates in the bone marrow and spleen, respectively, following transfer into irradiated mice, mature CMP- and CLP-derived B cells exhibit distinct functional responses. Specifically, CMP-derived B cells did not respond to mitogenic stimulation to the same degree as their CLP-derived counterparts and secrete lower levels of IgM and the inflammatory cytokines such as interleukin (IL)-6 and IL-10. Together, these data suggest the existence of multiple pathways for generating functionally distinct B cells from bone marrow precursors.

Original languageEnglish (US)
Pages (from-to)349-357
Number of pages9
JournalClinical and Experimental Immunology
Volume150
Issue number2
DOIs
StatePublished - Nov 2007

Keywords

  • B cells
  • Common lymphoid progenitor
  • Common myeloid progenitor
  • Cytokine

ASJC Scopus subject areas

  • Immunology

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    Yang, G. X., Lian, Z. X., Chuang, Y. H., Shu, S. A., Moritoki, Y., Lan, R., Wakabayashi, K., Ansari, A. A., Dorshkind, K., Ikehara, S., & Gershwin, M. E. (2007). Generation of functionally distinct B lymphocytes from common myeloid progenitors. Clinical and Experimental Immunology, 150(2), 349-357. https://doi.org/10.1111/j.1365-2249.2007.03493.x