General consideration on sialic Acid Chemistry

Hongzhi Cao, Xi Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

Sialic acids, also known as neuraminic acids, are a family of negatively charged α-keto acids with a nine-carbon backbone. These unique sugars have been found at the termini of many glycan chains of vertebrate cell surface, which play pivotal roles in mediating or modulating a variety of physiological and pathological processes. This brief review covers general approaches for synthesizing sialic acid containing structures. Recently developed synthetic methods along with structural diversities and biological functions of sialic acid are discussed.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages31-56
Number of pages26
Volume808
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume808
ISSN (Print)10643745

Keywords

  • Chemoenzymatic synthesis
  • Glycosylation
  • Sialic acid
  • Sialoside
  • Sialylation
  • Sialyltransferase

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Cao, H., & Chen, X. (2012). General consideration on sialic Acid Chemistry. In Methods in Molecular Biology (Vol. 808, pp. 31-56). (Methods in Molecular Biology; Vol. 808). https://doi.org/10.1007/978-1-61779-373-8_3