Gene therapy in wound healing: Present status and future directions

L. K. Branski, Clifford Pereira, D. N. Herndon, M. G. Jeschke

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalGene Therapy
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Keywords

  • Gene transfer
  • Growth factors
  • Liposomes
  • Wound healing

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Gene therapy in wound healing: Present status and future directions'. Together they form a unique fingerprint.

  • Cite this