Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1)

Takahiro Ito, Michael F Seldin, Makoto M. Taketo, Takeo Kubo, Shunji Natori

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report the organization and chromosome localization of the mouse transcription elongation factor S-II gene (Tcea1). This gene was found to be a single copy gene consisting of 10 exons spanning approximately 30 kb. Its organization was the same as those of the mouse testis-specific S-II gene (Tcea2) and Xenopus general S-II gene (xTFIIS.oA), but different from that of the human S-II gene family. We also identified a processed pseudogene (Tcea1- ps1) with a sequence highly homologous to those of S-II cDNAs but containing a translation termination codon within its open reading frame. Linkage analysis showed that Tcea1 and Tcea1-ps1 are mapped on mouse chromosomes 1 and 15, respectively. Relationships between Tcea1 and S-II cDNAs isolated so far are discussed. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalGene
Volume244
Issue number1-2
DOIs
StatePublished - Feb 22 2000

Keywords

  • Chromosome mapping
  • Gene structure
  • Processed pseudogene
  • Tcea1
  • Tcea1- ps1
  • Transcript elongation

ASJC Scopus subject areas

  • Genetics

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