Gene expression differs in susceptible and resistant amphibians exposed to batrachochytrium dendrobatidis

Evan A. Eskew, Barbara C. Shock, Elise E.B. Ladouceur, Michael K Keel, Michael R. Miller, Janet E Foley, Brian D. Todd

Research output: Contribution to journalArticle

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Abstract

Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation. It remains unclear whether the amphibian adaptive immune system plays a role in Bd defence. Here, we describe gene expression in two host species—one susceptible to chytridiomycosis and one resistant—following exposure to two Bd isolates that differ in virulence. Susceptible wood frogs (Rana sylvatica) had high infection loads and mortality when exposed to the more virulent Bd isolate but lower infection loads and no fatal disease when exposed to the less virulent isolate. Resistant American bullfrogs (R. catesbeiana)

Original languageEnglish (US)
Article number170910
JournalRoyal Society Open Science
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2018

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Keywords

  • Amphibian immunity
  • Chytridiomycosis
  • Comparative transcriptomics
  • Emerging infectious disease
  • Host defences
  • Host–Pathogen interactions

ASJC Scopus subject areas

  • General

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