Gene expression differs in susceptible and resistant amphibians exposed to batrachochytrium dendrobatidis

Evan A. Eskew, Barbara C. Shock, Elise E.B. Ladouceur, Michael K Keel, Michael R. Miller, Janet E Foley, Brian D. Todd

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation. It remains unclear whether the amphibian adaptive immune system plays a role in Bd defence. Here, we describe gene expression in two host species—one susceptible to chytridiomycosis and one resistant—following exposure to two Bd isolates that differ in virulence. Susceptible wood frogs (Rana sylvatica) had high infection loads and mortality when exposed to the more virulent Bd isolate but lower infection loads and no fatal disease when exposed to the less virulent isolate. Resistant American bullfrogs (R. catesbeiana)

Original languageEnglish (US)
Article number170910
JournalRoyal Society Open Science
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

amphibians
gene expression
Lithobates catesbeianus
infection
virulence
biodiversity
pathogens
Rana sylvatica
adaptive immunity

Keywords

  • Amphibian immunity
  • Chytridiomycosis
  • Comparative transcriptomics
  • Emerging infectious disease
  • Host defences
  • Host–Pathogen interactions

ASJC Scopus subject areas

  • General

Cite this

Gene expression differs in susceptible and resistant amphibians exposed to batrachochytrium dendrobatidis. / Eskew, Evan A.; Shock, Barbara C.; Ladouceur, Elise E.B.; Keel, Michael K; Miller, Michael R.; Foley, Janet E; Todd, Brian D.

In: Royal Society Open Science, Vol. 5, No. 2, 170910, 01.02.2018.

Research output: Contribution to journalArticle

Eskew, Evan A. ; Shock, Barbara C. ; Ladouceur, Elise E.B. ; Keel, Michael K ; Miller, Michael R. ; Foley, Janet E ; Todd, Brian D. / Gene expression differs in susceptible and resistant amphibians exposed to batrachochytrium dendrobatidis. In: Royal Society Open Science. 2018 ; Vol. 5, No. 2.
@article{834d2a0fcf14482f8269c224a7652f17,
title = "Gene expression differs in susceptible and resistant amphibians exposed to batrachochytrium dendrobatidis",
abstract = "Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation. It remains unclear whether the amphibian adaptive immune system plays a role in Bd defence. Here, we describe gene expression in two host species—one susceptible to chytridiomycosis and one resistant—following exposure to two Bd isolates that differ in virulence. Susceptible wood frogs (Rana sylvatica) had high infection loads and mortality when exposed to the more virulent Bd isolate but lower infection loads and no fatal disease when exposed to the less virulent isolate. Resistant American bullfrogs (R. catesbeiana)",
keywords = "Amphibian immunity, Chytridiomycosis, Comparative transcriptomics, Emerging infectious disease, Host defences, Host–Pathogen interactions",
author = "Eskew, {Evan A.} and Shock, {Barbara C.} and Ladouceur, {Elise E.B.} and Keel, {Michael K} and Miller, {Michael R.} and Foley, {Janet E} and Todd, {Brian D.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1098/rsos.170910",
language = "English (US)",
volume = "5",
journal = "Royal Society Open Science",
issn = "2054-5703",
publisher = "The Royal Society",
number = "2",

}

TY - JOUR

T1 - Gene expression differs in susceptible and resistant amphibians exposed to batrachochytrium dendrobatidis

AU - Eskew, Evan A.

AU - Shock, Barbara C.

AU - Ladouceur, Elise E.B.

AU - Keel, Michael K

AU - Miller, Michael R.

AU - Foley, Janet E

AU - Todd, Brian D.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation. It remains unclear whether the amphibian adaptive immune system plays a role in Bd defence. Here, we describe gene expression in two host species—one susceptible to chytridiomycosis and one resistant—following exposure to two Bd isolates that differ in virulence. Susceptible wood frogs (Rana sylvatica) had high infection loads and mortality when exposed to the more virulent Bd isolate but lower infection loads and no fatal disease when exposed to the less virulent isolate. Resistant American bullfrogs (R. catesbeiana)

AB - Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation. It remains unclear whether the amphibian adaptive immune system plays a role in Bd defence. Here, we describe gene expression in two host species—one susceptible to chytridiomycosis and one resistant—following exposure to two Bd isolates that differ in virulence. Susceptible wood frogs (Rana sylvatica) had high infection loads and mortality when exposed to the more virulent Bd isolate but lower infection loads and no fatal disease when exposed to the less virulent isolate. Resistant American bullfrogs (R. catesbeiana)

KW - Amphibian immunity

KW - Chytridiomycosis

KW - Comparative transcriptomics

KW - Emerging infectious disease

KW - Host defences

KW - Host–Pathogen interactions

UR - http://www.scopus.com/inward/record.url?scp=85043530357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043530357&partnerID=8YFLogxK

U2 - 10.1098/rsos.170910

DO - 10.1098/rsos.170910

M3 - Article

AN - SCOPUS:85043530357

VL - 5

JO - Royal Society Open Science

JF - Royal Society Open Science

SN - 2054-5703

IS - 2

M1 - 170910

ER -