Gene-environment interaction of body mass index and apolipoprotein e ε4 allele on cognitive decline

Kumar Rajan, Kimberly A. Skarupski, Heather E. Rasmussen, Denis A. Evans

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Genetic variation alone may not account for common chronic disease susceptibility. Rather, an interaction between genetic and environmental factors may clarify the underlying disease mechanism. Hence, we tested whether body mass index (BMI) modified the genetic association of the apolipoprotein E ε4 allele with cognitive decline. The data came from a longitudinal population-based sample of 4055 participants interviewed at 3-year intervals from 1993 to 2012. Cognitive function was assessed using a standardized global cognitive score and BMI was assessed at baseline and classified as normal, overweight, and obese. There were 1374 (34%) participants with the ε4 allele. In normal BMI participants, cognitive decline was 0.048 units/y without the ε4 allele, and increased by an additional 0.031 units/y with the ε4 allele. In overweight participants, cognitive decline was 0.038 units/y without the ε4 allele, and increased by an additional 0.026 units/y with the ε4 allele. Finally, in obese participants, cognitive decline was 0.038 units/y without the ε4 allele, and increased by an additional 0.014 units/y with the ε4 allele. The association of ε4 allele with cognitive decline was significantly lower in obese participants compared with normal BMI participants (P=0.003), thereby suggesting significant gene-environment interaction on cognitive decline.

Original languageEnglish (US)
Pages (from-to)134-140
Number of pages7
JournalAlzheimer Disease and Associated Disorders
Volume28
Issue number2
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Gene-Environment Interaction
Apolipoproteins
Body Mass Index
Alleles
Apolipoprotein E4
Cognitive Dysfunction
Disease Susceptibility
Cognition
Chronic Disease

Keywords

  • Apolipoprotein E
  • Body mass index
  • Cognitive decline
  • Cohort studies
  • Gene-environment interaction

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Gene-environment interaction of body mass index and apolipoprotein e ε4 allele on cognitive decline. / Rajan, Kumar; Skarupski, Kimberly A.; Rasmussen, Heather E.; Evans, Denis A.

In: Alzheimer Disease and Associated Disorders, Vol. 28, No. 2, 01.01.2014, p. 134-140.

Research output: Contribution to journalArticle

Rajan, Kumar ; Skarupski, Kimberly A. ; Rasmussen, Heather E. ; Evans, Denis A. / Gene-environment interaction of body mass index and apolipoprotein e ε4 allele on cognitive decline. In: Alzheimer Disease and Associated Disorders. 2014 ; Vol. 28, No. 2. pp. 134-140.
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