Gene Amplification

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gene amplification is the differential increase in a specific portion of the genome in comparison with the remainder. This process appears to be ubiquitous, occurring in most organisms, and has also been shown to occur in both germline and somatic cells. Gene amplification may be associated with normal developmental processes or occur as sporadic genetic events with either favorable (e.g., growth or survival advantage) or detrimental (e.g., tumorigenesis) consequences to the organism. More recently, somatic cell gene amplification has been extensively studied in human cancers. Amplification of proto-oncogenes can lead to or contribute to tumorigenesis and/or tumor progression. In certain instances, the amplified gene may be a useful target for cancer therapy.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages171-172
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013
Externally publishedYes

Keywords

  • Copy number
  • Gains
  • Predictive marker
  • Prognostic marker

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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