Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock

Xiaoxia Yang, Yu Kun Jennifer Zhang, Noriko Esterly, Curtis D. Klaassen, Yu-Jui Yvonne Wan

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The mammalian clock regulates major aspects of energy metabolism, including glucose and lipid homoeostasis as well as mitochondrial oxidative metabolism. This study is to identify specific patterns of circadian rhythms for lipid homoeostasis in both female and male mouse livers, and to clarify gender disparity in coupling the peripheral circadian clock to lipid metabolic outputs by nuclear receptors. To achieve this, profiling the diurnal hepatic expression of genes encoding circadian clocks, nuclear receptors and lipid metabolic enzymes was performed. Hepatic lipid levels including cholesterol, triglyceride and non-esterified fatty acids (NEFAs) were monitored over a 24-h period. The cosinor analysis revealed that several genes encoding nuclear receptors and enzymes involved in the lipid metabolic pathway were rhythmically expressed in liver in phase with the peripheral clocks, which were correlated with the diurnal changes of hepatic lipid levels. Gender disparity was observed for circadian characteristics including mesor and amplitude values, accompanied with advances in acrophases in female mouse livers. Accordingly, gender differences were also observed in diurnal lipid homoeostasis. The identification of cycling patterns for lipid metabolic pathways in both female and male mouse livers may shed light on the development of gender-based treatment for human diseases related to the coordination of the cellular clock and control of lipid homoeostasis.

Original languageEnglish (US)
Pages (from-to)609-623
Number of pages15
JournalJournal of Biochemistry
Issue number5
StatePublished - May 2009
Externally publishedYes


  • Circadian rhythm
  • Gender
  • Lipid homoeostasis
  • Liver
  • Nuclear receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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