Gender differences in correlations of cerebral glucose matabolic rates in young normal adults

N. P. Azari, S. I. Rapoport, C. L. Grady, Charles DeCarli, J. V. Haxby, M. B. Schapiro, B. Horwitz

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Correlational analysis of normalized regional cerebral metabolic data obtained by positron emission tomography, in healthy subjects in the 'resting' state (eyes covered, ears plugged) using [18F]2-fluuro-2-deoxy-dgllucose, demonstrated gender differences in patterns of functional associations. Fifteen women and 18 men (< 40 yr) were scanned with a Scanditronix PC1024-7B tomograph. The brain was divided into 65 regions of interest (ROIs). There were no differences between men and women in global or regional metabolic rates, or in metabolic right-left asymmetries. Although the total number of significant correlations did not differ between men and women, patterns differed: female correlations rF were more positive than male correlations rM more often than rM > rF; and most rF > rM cases involved left frontal and sensorimotor ROIs, whereas most rM > rF cases involved right sensorimotor and occipital ROIs. The finding demonstrate gender differences in the pattern of functional neocortical interactions at the 'resting' state.

Original languageEnglish (US)
Pages (from-to)198-208
Number of pages11
JournalBrain Research
Volume574
Issue number1-2
DOIs
StatePublished - Mar 6 1992
Externally publishedYes

Keywords

  • Brain
  • Cerebral metabolism
  • Correlation
  • Gender
  • Glucose
  • Human
  • Positron emission tomography

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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  • Cite this

    Azari, N. P., Rapoport, S. I., Grady, C. L., DeCarli, C., Haxby, J. V., Schapiro, M. B., & Horwitz, B. (1992). Gender differences in correlations of cerebral glucose matabolic rates in young normal adults. Brain Research, 574(1-2), 198-208. https://doi.org/10.1016/0006-8993(92)90817-S