Abstract
As the "baby boomers" age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury in the older individuals. Mucosal surfaces have the largest combined surface area in the body and are the site of important host microbe interactions, especially in the gut which is prone to injury, both from local and systemic insult. This susceptibility has been known to increase with age. Therefore it is important to understand the interplay between aging, injury and recovery at the mucosal surface. Sex hormones play an important role in the maintenance of the mucosal barrier function as well as the mucosa associated immune function in both genders. Menopause in women is a defined time period in which major hormonal changes occur such as a decline in systemic estradiol levels. The differential levels of sex hormones contribute to the sexual dimorphism seen in response to injury at the mucosal surface, prior to and following menopause. Thus the effect of sex hormone and aging on mucosal mechanisms in response to injury is an important area of investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 160-169 |
| Number of pages | 10 |
| Journal | Aging and Disease |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Aging
- Epithelial barrier function
- Estradiol
- Gut mucosa
- Hormones
- Menopause
- Microbial translocation
- Mucosal injury
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Cell Biology
- Clinical Neurology
- Pathology and Forensic Medicine
Cite this
Gender differences, aging and hormonal status in mucosal injury and repair. / Grishina, Irina; Fenton, Anne; Sankaran-Walters, Sumathi.
In: Aging and Disease, Vol. 5, No. 2, 2014, p. 160-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gender differences, aging and hormonal status in mucosal injury and repair
AU - Grishina, Irina
AU - Fenton, Anne
AU - Sankaran-Walters, Sumathi
PY - 2014
Y1 - 2014
N2 - As the "baby boomers" age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury in the older individuals. Mucosal surfaces have the largest combined surface area in the body and are the site of important host microbe interactions, especially in the gut which is prone to injury, both from local and systemic insult. This susceptibility has been known to increase with age. Therefore it is important to understand the interplay between aging, injury and recovery at the mucosal surface. Sex hormones play an important role in the maintenance of the mucosal barrier function as well as the mucosa associated immune function in both genders. Menopause in women is a defined time period in which major hormonal changes occur such as a decline in systemic estradiol levels. The differential levels of sex hormones contribute to the sexual dimorphism seen in response to injury at the mucosal surface, prior to and following menopause. Thus the effect of sex hormone and aging on mucosal mechanisms in response to injury is an important area of investigation.
AB - As the "baby boomers" age, the percentage of the population over sixty-five years of age is increasing rapidly. Chronic disease management is an important component in the care of the elderly. The effects of aging on different organ systems are also pertinent; such as the weakening homeostatic response to injury in the older individuals. Mucosal surfaces have the largest combined surface area in the body and are the site of important host microbe interactions, especially in the gut which is prone to injury, both from local and systemic insult. This susceptibility has been known to increase with age. Therefore it is important to understand the interplay between aging, injury and recovery at the mucosal surface. Sex hormones play an important role in the maintenance of the mucosal barrier function as well as the mucosa associated immune function in both genders. Menopause in women is a defined time period in which major hormonal changes occur such as a decline in systemic estradiol levels. The differential levels of sex hormones contribute to the sexual dimorphism seen in response to injury at the mucosal surface, prior to and following menopause. Thus the effect of sex hormone and aging on mucosal mechanisms in response to injury is an important area of investigation.
KW - Aging
KW - Epithelial barrier function
KW - Estradiol
KW - Gut mucosa
KW - Hormones
KW - Menopause
KW - Microbial translocation
KW - Mucosal injury
UR - http://www.scopus.com/inward/record.url?scp=84916884120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916884120&partnerID=8YFLogxK
U2 - 10.14336/AD.2014.0500160
DO - 10.14336/AD.2014.0500160
M3 - Article
VL - 5
SP - 160
EP - 169
JO - Aging and Disease
JF - Aging and Disease
SN - 2152-5250
IS - 2
ER -