GCP, a genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines

Jamie L. McCall, Rebekah A. Burich, Philip Mack

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Genistein combined polysaccharide (GCP), derived from soy bean extract, is comprised of deglycosylated isoflavones, such as genistein and daidzein. The goal of this work was to determine if GCP is effective in lymphoid cancers. In three human and four canine lymphoid cell lines, GCP inhibited proliferation and induced G2/M arrest. Additionally, increased apoptosis was observed in Ramos and Jurkat lines. These results demonstrate that GCP is effective in lymphoid cell lines of both human and canine origin. Due to its minimal toxicities, increased bioavailability, and in vitro efficacy, GCP may have clinical utility in the treatment of patients with lymphoma.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalLeukemia Research
Volume34
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • GCP
  • Genistein combined polysaccharide
  • Lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'GCP, a genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines'. Together they form a unique fingerprint.

  • Cite this