Gastrointestinal pythiosis in 10 dogs from California

N. A. Berryessa, Stanley L Marks, Patricia Pesavento, T. Krasnansky, S. K. Yoshimoto, Eric G Johnson, Amy M. Grooters

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Pythium insidiosum is an aquatic oomycete that causes severe segmental thickening of the canine gastrointestinal (GI) tract, resulting in weight loss, vomiting, diarrhea, and death. Infection in dogs previously has been observed primarily in the southeastern United States. Objective: To describe the clinicopathologic and epidemiologic findings associated with GI pythiosis in 10 dogs from California. Methods: Dogs were initially identified on the basis of supportive clinical findings and routine histology. Pythiosis was confirmed in each dog with at least one of the following: immunoblot serology, enzyme-linked immunosorbent assay serology, immunohistochemistry, and culture followed by species-specific polymerase chain reaction, rRNA gene sequencing, or both. Results: Between September 2003 and December 2006, GI pythiosis was confirmed in 1 dog from central California and 9 dogs that lived within a 30-mile radius of Davis, CA. Seven of 8 dogs for which environmental data were available had frequent access to flooded rice fields or other water sources. Esophageal lesions were present in 2 of 10 dogs. Common laboratory findings included eosinophilia (7/9), hypoalbuminemia (9/9), and hyperglobulinemia (8/9). Median survival time was 26.5 days (range, 0-122 days), and the disease was ultimately fatal in all 10 dogs. Conclusions and Clinical Importance: The geographic distribution of pythiosis has widened in recent years to include the western United States. Factors that may have contributed to this change include altered rice-farming practices and landscape irrigation. Veterinarians in California should be familiar with the clinicopathologic features associated with GI pythiosis to aid in early diagnosis and effective treatment.

Original languageEnglish (US)
Pages (from-to)1065-1069
Number of pages5
JournalJournal of Veterinary Internal Medicine
Volume22
Issue number4
DOIs
StatePublished - Jul 2008

Fingerprint

Pythiosis
Dogs
dogs
Serology
Pythium
Oomycetes
Southeastern United States
Pythium insidiosum
Hypoalbuminemia
Veterinarians
eosinophilia
Eosinophilia
early diagnosis
Western United States
Agriculture
rRNA Genes
vomiting
Vomiting
Gastrointestinal Tract
Canidae

Keywords

  • Canine
  • Eosinophilia
  • Fungal
  • Mycotic
  • Oomycete
  • Pythium insidiosum

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Gastrointestinal pythiosis in 10 dogs from California. / Berryessa, N. A.; Marks, Stanley L; Pesavento, Patricia; Krasnansky, T.; Yoshimoto, S. K.; Johnson, Eric G; Grooters, Amy M.

In: Journal of Veterinary Internal Medicine, Vol. 22, No. 4, 07.2008, p. 1065-1069.

Research output: Contribution to journalArticle

Berryessa, N. A. ; Marks, Stanley L ; Pesavento, Patricia ; Krasnansky, T. ; Yoshimoto, S. K. ; Johnson, Eric G ; Grooters, Amy M. / Gastrointestinal pythiosis in 10 dogs from California. In: Journal of Veterinary Internal Medicine. 2008 ; Vol. 22, No. 4. pp. 1065-1069.
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