Gastrointestinal lymphomas

Morphology, immunophenotype and molecular features

Marnelli A. Bautista-Quach, Christopher D. Ake, Mingyi Chen, Jun Wang

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Primary gastrointestinal lymphoma comprises 10-15% of all non-Hodgkin lymphomas and encompasses 30-40% of the total extranodal lymphomas. Approximately 60-75% of cases occur in the stomach, and then the small bowel, ileum, cecum, colon and rectum. Lymphoid neoplasms may consist of mature B, T and less commonly extranodal NK/T cells. Of these, the two most frequently encountered histologic subtypes are extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), where Helicobacter pylori infection is implicated in a number of cases, and diffuse large B cell lymphoma. Several B cell lymphomas are associated with chromosomal aberrations. Enteropathy-associated T cell lymphoma, type I in particular, usually arises in a background of celiac disease. T cell gene rearrangement confirms clonality. NK/T cell neoplasms are invariably associated with Epstein-Barr virus infection and are often aggressive; thus, differentiation from a benign NK-cell enteropathy is paramount. Although incidence of other hematopoietic malignancies in the gastrointestinal tract such as plasma cell myeloma associated with amyloidosis, plasmablastic lymphoma, Hodgkin disease, histiocytic sarcoma and mast cell sarcoma is extremely rare, these entities have been documented, with the latter two demonstrating aggressive clinical behavior. Endoscopic ultrasonography is an important adjunct in disease staging and follow-up. Conservative antibiotic treatment of stage I MALT lymphomas with associated Helicobacter pylori infection achieves good clinical outcome with high remission rate. Chemotherapy, radiation and rarely surgery are reserved for advanced diseases or cases resistant to conservative therapy and those not associated with Helicobacter pylori infection.

Original languageEnglish (US)
Pages (from-to)209-225
Number of pages17
JournalJournal of Gastrointestinal Oncology
Volume3
Issue number3
DOIs
StatePublished - 2012

Fingerprint

Marginal Zone B-Cell Lymphoma
Lymphoma
Helicobacter Infections
Helicobacter pylori
Natural Killer Cells
Mast-Cell Sarcoma
Enteropathy-Associated T-Cell Lymphoma
T-Lymphocyte Gene Rearrangement
Histiocytic Sarcoma
T-Lymphocytes
Endosonography
Epstein-Barr Virus Infections
Lymphoma, Large B-Cell, Diffuse
Cecum
Celiac Disease
B-Cell Lymphoma
Amyloidosis
Hematologic Neoplasms
Multiple Myeloma
Hodgkin Disease

Keywords

  • Gastrointestinal lymphomas
  • MALT lymphoma
  • NK/T-cell enteropathy

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Gastrointestinal lymphomas : Morphology, immunophenotype and molecular features. / Bautista-Quach, Marnelli A.; Ake, Christopher D.; Chen, Mingyi; Wang, Jun.

In: Journal of Gastrointestinal Oncology, Vol. 3, No. 3, 2012, p. 209-225.

Research output: Contribution to journalReview article

Bautista-Quach, Marnelli A. ; Ake, Christopher D. ; Chen, Mingyi ; Wang, Jun. / Gastrointestinal lymphomas : Morphology, immunophenotype and molecular features. In: Journal of Gastrointestinal Oncology. 2012 ; Vol. 3, No. 3. pp. 209-225.
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