Gastroduodenal sensory mechanisms and CCK in inhibition of gastric emptying in response to a meal

Helen E Raybould, Tilman T. Zittel, Helge H. Holzer, Kevin C K Lloyd, James H. Meyer

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The ability of nutrients in the intestinal lumen to exert feedback control over the proximal gastrointestinal tract function is well recognized, yet the control mechanisms are poorly defined. There is evidence that extrinsic sensory pathways from the intestine are required to initiate this regulatory process. Furthermore, CCK appears to be involved in the gastric response to several intestinal stimuli, such as fat, carbohydrate and protein. Our hypothesis is that nutrients release CCK from the intestine, which then stimulates intestinal mucosal afferents to signal reflex changes in gastric motor function and thus inhibit gastric emptying.

Original languageEnglish (US)
JournalDigestive Diseases and Sciences
Volume39
Issue number12 Supplement
DOIs
StatePublished - Dec 1994

Keywords

  • capsaicin
  • CCK
  • intestinal feedback inhibition
  • nutrients
  • sensory

ASJC Scopus subject areas

  • Gastroenterology

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