Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque

Jennifer L. Huff, Lori M. Hansen, Jay V Solnick

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Infection with Helicobacter pylori is usually asymptomatic but sometimes progresses to peptic ulcer disease or gastric adenocarcinoma. The development of disease involves both host and bacterial factors. In order to better understand host factors in pathogenesis, we studied the gastric transcription profile of H. pylori infection in the rhesus macaque by using DNA microarrays. Significant changes were found in the expression of genes important for innate immunity, chemokines and cytokines, cell growth and differentiation, apoptosis, structural proteins, and signal transduction and transcription factors. This broad transcription profile demonstrated expected up-regulation of cell structural elements and the host inflammatory and immune response, as well as the novel finding of down-regulation of heat shock proteins. These results provide a unique view of acute H. pylori infection in a relevant animal model system and will direct future studies regarding the host response to H. pylori infection.

Original languageEnglish (US)
Pages (from-to)5216-5226
Number of pages11
JournalInfection and Immunity
Volume72
Issue number9
DOIs
StatePublished - Sep 2004

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Helicobacter Infections
Macaca mulatta
Helicobacter pylori
Stomach
Stomach Diseases
Heat-Shock Proteins
Oligonucleotide Array Sequence Analysis
Peptic Ulcer
Chemokines
Innate Immunity
Cell Differentiation
Signal Transduction
Adenocarcinoma
Transcription Factors
Up-Regulation
Down-Regulation
Animal Models
Apoptosis
Cytokines
Gene Expression

ASJC Scopus subject areas

  • Immunology

Cite this

Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque. / Huff, Jennifer L.; Hansen, Lori M.; Solnick, Jay V.

In: Infection and Immunity, Vol. 72, No. 9, 09.2004, p. 5216-5226.

Research output: Contribution to journalArticle

Huff, Jennifer L. ; Hansen, Lori M. ; Solnick, Jay V. / Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque. In: Infection and Immunity. 2004 ; Vol. 72, No. 9. pp. 5216-5226.
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